Aniseed Eo, Cautions

<p>Applications of Aniseed EO should be limited to inhalation therapy.</p>

<p>The compound has been reported to show estrogenic, antiprogestational, androgenic and antiandrogenic activities</p>

<h2>Adverse reactions</h2>

<p>
Contact dermatitis was reported in a cake factory worker after external exposure to a 5% concentration of Anise EO. Occasional allergic reactions to the oil affecting the skin, respiratory tract and gastrointestinal tract are reported. Inhalation of powdered Aniseed
induced an allergic effect in one subject with asthma. Skin-prick tests showed a positive reaction to the fruits and the patient had high specific anti-aniseed immunoglobulin E antibodies in his blood . Anethole toxicity in infants has been reported, and presents clinically with symptoms of hypertonia, continued crying, atypical ocular movements, twitching,
cyanosis, vomiting and lack of appetite . Ingestion of 1.0–5.0 ml of the oil can result in nausea, vomiting, seizures and pulmonary edema. In cases of overdose (> 50 mg/kg), the ingestion of milk and alcohol is contraindicated owing to increased resorption.</p>

<h2>Contraindications</h2>

<p>Anise EO  is  contraindicated in cases of known allergy to aniseed and anethole . Owing to the traditional use of the oil as an emmenagogue and to induce labor, its experimental estrogenic and potential mutagenic effects, and reports of anethole toxicity in infants, use of the oil in pregnancy and nursing, and in children under the age of 12 years is contraindicated.</p>