Proline
18 proven health benefits:
. Amino Acid:
- Proline is one of the 20 building blocks of proteins, but it's unique compared to others.
- Unlike most amino acids with an amino group on the side chain, proline has a cyclic structure, forming a ring. This unique structure gives it special properties.
2. Properties:
- Non-essential: The body can synthesize proline from other amino acids, so it's not essential to obtain it from the diet.
- Hydrophobic: While it has a polar carboxyl group, the cyclic structure makes it less water-soluble than other amino acids.
- Structural role: Proline plays a crucial role in protein structure due to its unique shape. It can disrupt regular secondary structures like alpha helices and beta sheets but also helps stabilize turns and bends in proteins.
- Signaling: Proline can act as a signaling molecule within cells, participating in processes like cell differentiation and wound healing.
3. Sources:
- Found in various protein-rich foods like meat, fish, dairy, legumes, and nuts.
- Some vegetables like spinach and broccoli also contain proline.
4. Potential Benefits:
- Studies suggest it might have beneficial effects on skin health, wound healing, and joint function.
- Research is ongoing to explore its potential role in managing certain health conditions.
ARTICLES/STUDIES
Risk Factors
Benefits
Cancer
- A mixture containing ascorbic acid, lysine, proline and green tea extract inhibits angiogenesis of tumor cells.
- A mixture containing ascorbic acid, lysine, proline and green tea extract inhibits breast cancer.
- A nutrient mixture inhibited tumor weight and tumor burden by 53% and 48% respectively.
- A nutrient mixture inhibits a human liver cancer cell line.
- A nutrient mixture, containing ascorbic acid, lysine, proline, green tea extract exhibit significant antiproliferative effects against aggressive non-Hodgkin's lymphoma cell lines.
- A specific mixture of nutrients suppresses ovarian cancer A-2780 tumor incidence, growth, and metastasis to lungs.
- Supplementation with a nutrient mixture in female mice demonstrated a potent inhibition of tumor growth and enhancement of extracellular matrix proteins.
- A combination of lysine, proline, arginine, ascorbic acid and green tea extract inhibits a pancreatic cancer cell line.
- A combination of Lysine, Proline, Vitamin C, Arginine, Polyphenols, NAC (N-acetyl-L-cysteine), Selenium, Copper, Manganese induces apoptosis in HTLV-1 positive and negative malignant T-cells.