Notes 3

Children

+1 Antiviral Innate Immune Pathways
+1b Hypocretin/Orexin System
10 Endothelial Dysfunction and Low Nitric Oxide Production
10 Peptides and Neuropeptides
17 DNA Methylation Modifications
1a Decreases in Sphingolipid, glycosphingolipid, phospholipid, purine, microbiome aromatic amino acid and branch chain amino acid metabolites, as well as in flavine adenine nucleotide (FAD) and lathosterol
2 Reticular Activating System
3 Alterations in normal energy metabolic processes and abnormalities in cellular bioenergetics
3 Somnogen in Cerebrospinal Spinal Fluid of Hypersomnia Patients, and (Endogenous) Enhancement of GABAA Receptors
8 Thalamus
abnormal truncated form of ribonuclease L (37-kDa RNase L)
Abnormalities in CFS (listing of 1,000 studies in Fourty Five Catagories)
Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome
Antiviral Pathway Deregulation of Chronic Fatigue Syndrome Induces Nitric Oxide Production in Immune Cells That Precludes a Resolution of the Inflammatory Response
Ascending Arousal Pathway (ARAS)
CFS Laboratory Findings (links)
Cognitive Dysfunction
Coxsackievirus B and echovirus (CVB & EV)
Drug Trials
Environmental Toxins
Epstein Barr EBV
Hibernation and Dauer State Similarities
Hormone disruptors
Hypersomnolence, Hypersomnias
Hypocretin (Orexin) Neurons
Long Term Sequelae of TBI
Low Level Inflamation (on-going state of low level over-activity)
Mental Health
Mold, Yeast and Fungus
Other Therapies
Parasites
Posterior Hypothalamus
Postulated vasoactive neuropeptide immunopathology affecting the blood-brain/blood-spinal barrier in certain neuropsychiatric fatigue-related conditions: A role for phosphodiesterase inhibitors in treatment
Proactive vs. Hyper-Reactive Thinking
Stimulation of Hypothalamic Mast Cells by Environmental Neuroimmune Pathogenic And stress triggers activates microglia leading to focal inflammation in the brain
Symptoms include
Treatment with Flumazenil (GABAA receptor antagonist)

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