NAD

From: 'NAD: The Biological Rocket Fuel that Gives You Energy' <a href="https://www.healthrising.org/forums/threads/nad-the-biological-rocket-fuel-that-gives-you-energy.4684/">https://www.healthrising.org/forums/threads/nad-the-biological-rocket-fuel-that-gives-you-energy.4684/</a>

NAD stands for nicotinamide adenine dinucleotide, which is the chemical term for a molecule that reacts with oxygen in the mitochondria in every cell of your body in order to create energy so you can move, breathe, pump blood, digest food, think, and generally, live your life.

Lack of this essential cellular fuel is now recognized as a key feature of chronic fatigue, apathy, depression, anxiety, alcohol and drug addiction, weak immune system (infections and cancer), muscle pain and weakness, headaches, memory disturbance, sleep problems, focus and concentration defects and other chronic diseases. NAD deficiency may be an unrecognized epidemic of cellular disease.

NAD is an activated form of vitamin B3 which becomes a coenzyme when it is bound with hydrogen becoming NADH. Hydrogen, as in hydrogen bomb, is the explosive power that the body uses, along with oxygen, to make energy. Liquid hydrogen and liquid oxygen explode when blended together becoming the fuel that propels rockets into the sky. Hydrogen is so explosive that it must be safely inserted into a molecule so that it can be used by the body. NAD is the carrier for reactive hydrogen as it becomes NADH.

This is how it works. We eat carbohydrates, proteins and fats which provide the chemicals that enter the Citric Acid Cycle, a molecular roundabout that produces NADH. The NAD is now “loaded” with hydrogen (NADH) which in turn enters the electron transport chain in the mitochondria and is “sparked” with oxygen and the outcome is energy, or, ATP, along with water. ATP, or adenosine triphospate, is the fuel for the heart to beat, the muscles to contract and for every cellular energy requirement with in the 100 trillion cells of the body.

It is clear to see how important NADH is for the body as it is involved in every bodily function and catalyzes more than a thousand metabolic reactions in the organs and tissues. The heart uses the most NAD as it beats around 86,000 times daily. The brain consumes about one-third of all the energy produced by the body. Often an energy deficiency is first detected in the brain with poor concentration, difficulty focusing, and attention deficit. If the energy shortage lasts long enough, brain neurons cannot synthesize neurotransmitters, the molecules of consciousness, such as serotonin, dopamine, and noradrenaline, and we experience anxiety, depression, sleep disturbance and other mood changes.

Let us take a look at some of the functions of NADH in the body:

Increases energy in heart cells

Increases energy in brain cells

Protects and repairs DNA, reducing DNA mutations which contribute to atherosclerosis, cancer, immunodeficiency, rheumatoid arthritis, and much more

The “most powerful antioxidant” in the body according to Dr. Richard Passwater in his book NADH-The Energizing Coenzyme

Lowers cholesterol

Lowers blood pressure

Strengthens the immune system

Stimulates production of dopamine, serotonin, and noradrenaline, thereby improving moods

Stimulates nitric oxide production, thereby improving blood flow in the body

From: Healthrising user doerfast on 'NAD: The Biological Rocket Fuel that Gives You Energy' https://www.healthrising.org/forums/threads/nad-the-biological-rocket-fuel-that-gives-you-energy.4684/

The following are precursors (raw materials) from which NAD+ can be produced:

Nicotinamide Riboside (NR)

Tryptophan (L-Trp)

Nicotinic Acid (NA, Vitamin B3)

Nicotinamide (NAM, also called no flush Niacin)

Nicotinamide Mononucleotide (NMN)

NAD supplement does NOT cross the mitochondria inner membrane. NAD+ (the oxidized form of NADH ) does not enter the cell. NADH is the only moleciule that passes the cell membrane and increases the ATP energy in the cell. In the cell NADH is oxidized to NAD* and water. Hence NADH is the only molecule able to increase intracellular levels of NAD+. NR is a charged molecule and a charged molecule can not penetrate a lipid membrane such as the cell membrane. NADH penetrates the cell membrane and increases ATP in the cell (see attached publication). On Fig. 4 you can see that only NADH but neither Nicotinamide nor NAD+ goes into the cell and increases ATP energy there.

NADH cannot simply pass into mitochondria for oxidation by the respiratory chain, because the inner mitochondrial membrane is impermeable to NADH and NAD+. The solution is that electrons from NADH, rather than NADH itself, are carried across the mitochondrial membrane. One of several means of introducing electrons from NADH into the electron transport chain is the glycerol 3-phosphate shuttle (Figure 18.37). The first step in this shuttle is the transfer of a pair of electrons from NADH to dihydroxyacetone phosphate, a glycolytic intermediate, to form glycerol 3-phosphate.This reaction is catalyzed by a glycerol 3-phosphate dehydrogenase in the cytosol. Glycerol 3-phosphate is reoxidized to dihydroxyacetone phosphate on the outer surface of the inner mitochondrial membrane by a membrane-bound isozyme of glycerol 3-phosphate dehydrogenase. An electron pair from glycerol 3-phosphate is transferred to a FAD prosthetic group in this enzyme to form FADH2. This reaction also regenerates dihydroxyacetone phosphate.

From discussion 'Anyone Tried NADH for Energy?' on http://forums.phoenixrising.me/index.php?threads/anyone-tried-nadh-for-energy.4068/page-2

hi, I have just order a product which says its better absorbed then nadh, its called nad. it says its not altered by the acids in the stomach, what doesnt make sense is its subligual so u would think that stomach acid wouldnt be a problem. Anyway im going to give it a try and see how it go's, its now brand from iherb http://www.iherb.com/Now-Foods-NAD-25-mg-60-Lozenges/711?at=0 , i have had some response from normal nadh 20mg sublingual, like a caffeine hit i suppose. Anyone else tried this version? be interested to know how u went. The reviews on iherb were very positive but suppose there biast too, lol.