Allopregnanolone
<p>Testosterone Downregulates Allopregnenolone</p>
<p>From: Traumatic Brain Injury, Panhypopituitarism and Hormonal Evaluations as a Standard of Care
<a id="null" class="null" href="http://www.nevadaosteopathic.org/attachments/article/33/Clearfield%20Panhypopituitarism%20and%20TBI.pdf">http://www.nevadaosteopathic.org/attachments/article/33/Clearfield%20Panhypopituitarism%20and%20TBI.pdf</a> </p>
<p>Intracranially Produced Hormones: Etiology of Hormone Deficiency in TBI
Progesterone, allo progesterone, and DHEA protect neurons in TBI and cerebrovascular events.</p>
<p>– Protects nerves from oxidative stress
– Promotes neuroregeneration
– Regenerates myelin
– Reduces inflammatory cytokines
– Reduces interleukins
• Modulates neuronal and behavioral functions.
•Anxiolytic, antidepressant, anti-aggressive, anti-stress, anti-convulsant</p>
<p>Alzheimer’s and TBI Victims both exhibit a deficiency in allopregnanolone in their frontal lobes Neuro (Centrally Produced) Steroids – Regulate Neurotransmitters – Act as “Micro-Hormones” fine tuning the “Macro-Hormones” activity in brain – Failure of Neurosteroid System=Erratic Brain Transmissions – Expressed as depression, suicide, anxiety, panic attacks, phobia, psychosis</p>
<p>From: Traumatic Brain Injury, Panhypopituitarism and Hormonal Evaluations as a Standard of Care
<a id="null" class="null" href="http://www.nevadaosteopathic.org/attachments/article/33/Clearfield%20Panhypopituitarism%20and%20TBI.pdf">http://www.nevadaosteopathic.org/attachments/article/33/Clearfield%20Panhypopituitarism%20and%20TBI.pdf</a> </p>
<p>Intracranially Produced Hormones: Etiology of Hormone Deficiency in TBI
Progesterone, allo progesterone, and DHEA protect neurons in TBI and cerebrovascular events.</p>
<p>– Protects nerves from oxidative stress
– Promotes neuroregeneration
– Regenerates myelin
– Reduces inflammatory cytokines
– Reduces interleukins
• Modulates neuronal and behavioral functions.
•Anxiolytic, antidepressant, anti-aggressive, anti-stress, anti-convulsant</p>
<p>Alzheimer’s and TBI Victims both exhibit a deficiency in allopregnanolone in their frontal lobes Neuro (Centrally Produced) Steroids – Regulate Neurotransmitters – Act as “Micro-Hormones” fine tuning the “Macro-Hormones” activity in brain – Failure of Neurosteroid System=Erratic Brain Transmissions – Expressed as depression, suicide, anxiety, panic attacks, phobia, psychosis</p>
<p><img src="/bfe80933-4968-4bfe-94e0-4c38fc353a79.png" /></p>