7 Glycinergic system
<p>From: <a href="http://fblt.cz/en/skripta/regulacni-mechanismy-2-nervova-regulace/5-neurotransmisni-systemy/">4. Neurotransmitter Systems • Functions of Cells and Human Body</a>
Glycinergic system</p>
<p>Glycine is an inhibitory neurotransmitter. Its effect in the CNS is mediated by an ionotropic receptor coupled to a chloride channel causing membrane hyperpolarization. It can be found at a high density in the spinal gray matter, where it is the main neurotransmitter of inhibitory interneurons.</p>
<p>In addition to its inhibitory effect it is also a modulator of NMDA receptor activity, where it can cause excitatory effects via facilitating the activity of the glutamatergic system.</p>
<p><strong>Clinical correlation:</strong></p>
<p>Strychnine is a blocker of the glycine receptor. By inhibiting inhibitory interneurons in the spinal gray matter it causes uncoordinated spread of stimulation causing muscle spasm. Strychnin has a strong bitter taste, it is one of the most bitter substances.</p>