DHEA

Dehydroepiandrosterone (DHEA), also known as androstenolone, is an <a class="mw-redirect" title="Endogenous" href="https://en.wikipedia.org/wiki/Endogenous">endogenous</a> <a title="Steroid hormone" href="https://en.wikipedia.org/wiki/Steroid_hormone">steroid hormone</a>.<a href="https://en.wikipedia.org/wiki/Dehydroepiandrosterone#cite_note-pmid16293766-4">[4]</a> It is one of the most abundant circulating <a title="Steroid" href="https://en.wikipedia.org/wiki/Steroid">steroids</a> in humans,<a href="https://en.wikipedia.org/wiki/Dehydroepiandrosterone#cite_note-5">[5]</a>in whom it is produced in the <a title="Adrenal gland" href="https://en.wikipedia.org/wiki/Adrenal_gland">adrenal glands</a>,<a href="https://en.wikipedia.org/wiki/Dehydroepiandrosterone#cite_note-6">[6]</a> the <a title="Gonad" href="https://en.wikipedia.org/wiki/Gonad">gonads</a>, and the <a title="Brain" href="https://en.wikipedia.org/wiki/Brain">brain</a>.<a href="https://en.wikipedia.org/wiki/Dehydroepiandrosterone#cite_note-7">[7]</a> It functions as a <a title="Metabolic intermediate" href="https://en.wikipedia.org/wiki/Metabolic_intermediate">metabolic intermediate</a> in the <a title="Biosynthesis" href="https://en.wikipedia.org/wiki/Biosynthesis">biosynthesis</a> of the <a title="Androgen" href="https://en.wikipedia.org/wiki/Androgen">androgen</a> and <a title="Estrogen" href="https://en.wikipedia.org/wiki/Estrogen">estrogen</a> <a title="Sex steroid" href="https://en.wikipedia.org/wiki/Sex_steroid">sex steroids</a> both in the gonads and in various other <a title="Tissue (biology)" href="https://en.wikipedia.org/wiki/Tissue_(biology)">tissues</a>.<a href="https://en.wikipedia.org/wiki/Dehydroepiandrosterone#cite_note-pmid16293766-4">[4]</a><a href="https://en.wikipedia.org/wiki/Dehydroepiandrosterone#cite_note-pmid16524719-8">[8]</a><a href="https://en.wikipedia.org/wiki/Dehydroepiandrosterone#cite_note-Scott1996-9">[9]</a> However, DHEA also has a variety of potential biological effects in its own right, binding to an array of <a title="Nuclear receptor" href="https://en.wikipedia.org/wiki/Nuclear_receptor">nuclear</a>and <a title="Cell surface receptor" href="https://en.wikipedia.org/wiki/Cell_surface_receptor">cell surface receptors</a>,<a href="https://en.wikipedia.org/wiki/Dehydroepiandrosterone#cite_note-pmid16684650-10">[10]</a> and acting as a <a title="Neurosteroid" href="https://en.wikipedia.org/wiki/Neurosteroid">neurosteroid</a> and modulator of <a title="Neurotrophic factor receptor" href="https://en.wikipedia.org/wiki/Neurotrophic_factor_receptor">neurotrophic factor receptors</a>.<a href="https://en.wikipedia.org/wiki/Dehydroepiandrosterone#cite_note-pmid11281367-11">[11]</a>

In the United States, DHEA is sold as an <a class="mw-redirect" title="Over-the-counter" href="https://en.wikipedia.org/wiki/Over-the-counter">over-the-counter</a> <a title="Dietary supplement" href="https://en.wikipedia.org/wiki/Dietary_supplement">supplement</a>, and <a title="Medication" href="https://en.wikipedia.org/wiki/Medication">medication</a>, called <a title="Prasterone" href="https://en.wikipedia.org/wiki/Prasterone">prasterone</a>.

Disruption with DHEA levels connected to th1 and 2 levels

From: 'Chronic Fatigue Syndrome, A Roadmap for Testing and Treatment' <a href="https://sites.google.com/site/cfstestingandtreatmentroadmap/home">https://sites.google.com/site/cfstestingandtreatmentroadmap/home</a>
improves pain, fatigue, anxiety, memory and sexual problems in ME/CFS patients.<a href="http://www.ncbi.nlm.nih.gov/pubmed/19078357" target="_blank" rel="nofollow">1</a>