high-fructose corn syrup (HFCS)

High-fructose corn syrup (HFCS)—also called glucose-fructose syrup<a href="http://en.wikipedia.org/wiki/High-fructose_corn_syrup#cite_note-0" >[1]</a><a href="http://en.wikipedia.org/wiki/High-fructose_corn_syrup#cite_note-1" >[2]</a> in the UK, glucose/fructose<a href="http://en.wikipedia.org/wiki/High-fructose_corn_syrup#cite_note-2" >[3]</a> in Canada, and high-fructose maize syrup in other countries—comprises any of a group of <a href="http://en.wikipedia.org/wiki/Corn_syrup" title="Corn syrup" >corn syrups</a> that has undergone <a href="http://en.wikipedia.org/wiki/Enzymatic" title="Enzymatic" class="mw-redirect" >enzymatic</a> processing to convert some of its <a href="http://en.wikipedia.org/wiki/Glucose" title="Glucose" >glucose</a> into <a href="http://en.wikipedia.org/wiki/Fructose" title="Fructose" >fructose</a> to produce a desired <a href="http://en.wikipedia.org/wiki/Sweetness" title="Sweetness" >sweetness</a>.

In the <a href="http://en.wikipedia.org/wiki/United_States" title="United States" >United States</a>, consumer foods and products typically use high-fructose corn syrup as a sweetener. It has become very common in processed foods and beverages in the U.S., including

<a href="http://en.wikipedia.org/wiki/Bread" title="Bread" >breads</a>, <a href="http://en.wikipedia.org/wiki/Breakfast_cereal" title="Breakfast cereal" >cereals</a>, <a href="http://en.wikipedia.org/wiki/Breakfast_bar" title="Breakfast bar" class="mw-redirect" >breakfast bars</a>, <a href="http://en.wikipedia.org/wiki/Cold_cut" title="Cold cut" >lunch meats</a>, <a href="http://en.wikipedia.org/wiki/Yogurt" title="Yogurt" >yogurts</a>, <a href="http://en.wikipedia.org/wiki/Soup" title="Soup" >soups</a>, and <a href="http://en.wikipedia.org/wiki/Condiment" title="Condiment" >condiments</a>.<a href="http://en.wikipedia.org/wiki/High-fructose_corn_syrup#cite_note-3" >[4]</a>

According to the USDA, HFCS consists of 24% water, and the rest sugars. The most widely used varieties of high-fructose corn syrup are: HFCS 55 (mostly used in soft drinks), approximately 55% fructose and 42% glucose; and HFCS 42 (used in beverages, processed foods, cereals and baked goods), approximately 42% fructose and 53% glucose.<a href="http://en.wikipedia.org/wiki/High-fructose_corn_syrup#cite_note-4" >[5]</a><a href="http://en.wikipedia.org/wiki/High-fructose_corn_syrup#cite_note-5" >[6]</a> HFCS-90, approximately 90% fructose and 10% glucose, is used in small quantities for specialty applications, but primarily is used to blend with HFCS 42 to make HFCS 55.<a href="http://en.wikipedia.org/wiki/High-fructose_corn_syrup#cite_note-6" >[7]</a>

In the U.S., HFCS is among the sweeteners that have primarily replaced <a href="http://en.wikipedia.org/wiki/Sucrose" title="Sucrose" >sucrose</a> (table sugar) in the food industry. Factors for this include governmental production quotas of domestic sugar, subsidies of U.S. corn, and an import tariff on foreign sugar; all of which combine to raise the price of sucrose to levels above those of the rest of the world, making HFCS cheaper for many sweetener applications. Critics of the extensive use of HFCS in food sweetening argue that the highly processed substance is more harmful to humans than regular sugar, contributing to weight gain by affecting normal appetite functions,<a href="http://en.wikipedia.org/wiki/High-fructose_corn_syrup#cite_note-7" >[8]</a> and that in some foods HFCS may be a source of mercury, a known neurotoxin.<a href="http://en.wikipedia.org/wiki/High-fructose_corn_syrup#cite_note-Dufault2009-8" >[9]</a><a href="http://en.wikipedia.org/wiki/High-fructose_corn_syrup#cite_note-9" >[10]</a><a href="http://en.wikipedia.org/wiki/High-fructose_corn_syrup#cite_note-10" >[11]</a><a href="http://en.wikipedia.org/wiki/High-fructose_corn_syrup#cite_note-11" >[12]</a> The <a href="http://en.wikipedia.org/wiki/Corn_Refiners_Association" title="Corn Refiners Association" >Corn Refiners Association</a>disputes these claims and maintains that HFCS is comparable to table sugar.<a href="http://en.wikipedia.org/wiki/High-fructose_corn_syrup#cite_note-12" >[13]</a> Studies by the <a href="http://en.wikipedia.org/wiki/American_Medical_Association" title="American Medical Association" >American Medical Association</a> suggest "it appears unlikely that HFCS contributes more to obesity or other conditions than sucrose", but welcome further independent research on the subject.<a href="http://en.wikipedia.org/wiki/High-fructose_corn_syrup#cite_note-13" >[14]</a> Further reviews in the clinical literature have disputed the links between HFCS and obesity,<a href="http://en.wikipedia.org/wiki/High-fructose_corn_syrup#cite_note-White2008-14" >[15]</a> diabetes,<a href="http://en.wikipedia.org/wiki/High-fructose_corn_syrup#cite_note-15" >[16]</a> and <a href="http://en.wikipedia.org/wiki/Metabolic_syndrome" title="Metabolic syndrome" >metabolic syndrome</a>,<a href="http://en.wikipedia.org/wiki/High-fructose_corn_syrup#cite_note-White2008-14" >[15]</a> and concluded that HFCS is no different from any other sugar in relationship to these diseases. HFCS has been classified <a href="http://en.wikipedia.org/wiki/Generally_recognized_as_safe" title="Generally recognized as safe" >generally recognized as safe</a> (GRAS) by the <a href="http://en.wikipedia.org/wiki/U.S._Food_and_Drug_Administration" title="U.S. Food and Drug Administration" class="mw-redirect" >U.S. Food and Drug Administration</a> since 1976.<a href="http://en.wikipedia.org/wiki/High-fructose_corn_syrup#cite_note-FDAC-16" >[17]</a> Yet further study showed that with dietary zinc (Zn) loss and copper (Cu) gain from the consumption of high fructose corn syrup (HFCS), metabolic processes required to eliminate heavy metals are impaired in children with autism.<a href="http://en.wikipedia.org/wiki/High-fructose_corn_syrup#cite_note-Dufault2012-17" >[18]</a>