Giesy, JP

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* Visiting Professor, National Institute of Advanced Industrial Science and Technology (AIST)

* Institute for Environmental Management Technology (EMTECH), Japan, 2004-Present

* Adjunct Professor, Department of Veterinary Biomedical Sciences, Western College of Veterinary

Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada, 2004-Present

* Chair Professor at large, City University of Hong Kong, Hong Kong, China; 2003-Present

* Concurrent Professor: Nanjing University, Nanjing, China; 2003-Present

* National Food Safety and Toxicology Center; 1997-Present

* Center for Integrative Toxicology; 1981-Present

* Ecology, Evolution and Behavior Program Faculty; 1986-Present

* Center for Hazardous Waste Management; 1990-Present

* Canadian Studies Center; 1983-Present

* NIEHS Training Grant Faculty; 1990-Present

* USDI Water Science Fellow Training Faculty; 1985-Present

* Preceptor NIH Training Grant (Pathology/Veterinary Medicine); 1981-Present

china, bromides

John P. Giesy

Professor Giesy was born in 1948 in Youngstown Ohio, but considers himself a Michigander, since he has lived most of his life in the state

of Michigan. He attended Alma College in Alma, Michigan where, in 1970, he obtained a B.S. Degree, Summa cum laude with honors in

Biology. Prof. Giesy obtained Masters and Doctor of Philosophy Degrees in Limnology from Michigan State University in 1971 and 1974,

respectively. From 1974 until 1981 he was affiliated with the Savannah River Ecology Laboratory and a faculty member in the Institute of

Ecology and Department of Zoology at the University of Georgia.

Currently, he is Distinguished Professor of Zoology at Michigan State

University in East Lansing, Michigan, where he is also a Professor of Veterinary Medicine and on the faculties of the Institute for

Environmental Toxicology and National Food Safety and Toxicology Center. He is a NIEHS Preceptor and member of the National

Institutes of Health Faculty. Prof. Giesy considers himself an aquatic toxicologist with interests in many aspects of this field, including

both the fates and effects of potentially toxic compounds and elements, particularly in the area of ecological risk assessment. He has

conducted research into the movement, bioaccumulation and effects of toxic substances at different levels of biological organization,

ranging from biochemical to ecosystem.

Prof. Giesy has done extensive research in the areas of metal speciation, multispecies toxicity

testing, biochemical indicators of stress in aquatic organisms, fate and effects of PAHs, halogenated hydrocarbons, including chlorinated

dibenzo-dioxins and -furans, PCBs and pesticides. In addition to his work in aquatic toxicology, Prof. Giesy has become world-famous for

his wildlife toxicology studies, particularly in the area of endocrine modulating compounds. In addition to his work as an ecologist,

biochemical toxicologist he is a world-class environmental chemist, having developed and applied both analytical and bio-analytical

techniques to environmental issues. He discovered the phenomenon of photo-enhanced toxicity of organic compounds, such as PAHs. His

studies include both laboratory and field as well as mesocosm studies and apply tools from molecular biology to ecosystem-level. He was

the first to discover perfluorinated compounds in the environment, an important new class of environmental contaminants. Currently, Prof.

Giesy and his research group are actively studying the toxicity and reproductive effects of organic compounds, with special emphasis on

herbicides, chlorinated dioxins and perfluorinated compounds. Studies are being conducted in the field and laboratory on fish, fish-eating

birds and mammals in the Great Lakes region, including mink and raptors such as hawks and eagles and in marine mammals.

Prof. Giesy

is an expert in ecologicalrisk assessmentsof both industrial and agricultural chemicals. Prof. Giesy has been active in the development

and application of methods for the assessment of the toxicity of contaminated sediments, especially in the North American Great Lakes.

Prof. Giesy has received $41,279,623 from local, state, federal and international agencies and organizations to conduct his research, which

has resulted in the publication of 526 peer-reviewed articles and 826 lectures, world-wide. Three times, (1997 & 1999, 2002) a paper on

which he was a co-author has been selected as the best paper published in Environ. Toxicol. & Chem. In 2001, a paper he co-authored on

probabilistic risk assessments was selected as the best paper by Human and Environmental Risk Assessment. He has authored five books

and edited six books. Two of his books Microcosms in Ecological Research and Sediments: The Chemistry and Toxicology of In-Place

Pollutants have become classics.

His research is much used and cited by other researchers--Prof Giesy is in the top 0.5% of active authors

(ISI Current Contents: ISIHighlyCited.com) and was the 5th most cited author in the field of Ecology/Environmental Science over the

period 1994-2004 (In-Cites; http://www.in-cites.com/top/2004/fourth04-env.html). His research has been featured in a number of

magazine and newspaper articles.

Prof. Giesy is the member of many editorial boards and is the editor of the Environmental Toxicology

and Risk Assessment section of Chemosphere. Prof. Giesy works frequently in Europe with many universities, research establishments and

governments. He has served as a member of US EPA Science Advisory Boards and a member of six National Academy of Sciences

panels, including: 1) Endocrine Disruptors, 2) Remediation of PCB-Contaminated Sediments and 3) Bioavailability of Residues from

Sediments and Soils.

Prof. Giesy currently serves on the Boards of Scientific Councilors (BOSC) of the National Toxicology Program

(NTP) of the National Institutes of Health (NIH) and the US EPA Office of Research and Development (ORD) (Executive Committee).

Prof. Giesy has received a number of distinctions and awards including: In 1990 he was the recipient of the Sigma Xi Meritorious

Research Award. In 1993 he received the title of Distinguished Professor from Michigan State University. Prof. Giesy is also the

recipient of the Chevron Distinguished Lectureship Award for his research on the toxic effects of environmental contaminants on wildlife

and the CIBA-GEIGY Agricultural Recognition Award for his work on microcosms and pesticides and the Willard F. Shepard Award

from the Michigan Water Pollution Control Assoc. In 1994 Prof.

Giesy received the prestigious Vollenweider Medal for Aquatic Sciences

from the National Water Research Institute of Canada for his work on contaminants in the North American Great Lakes. In 1995 Dr. Giesy

received theFounders Award, which is the highest award given by the Society of Environmental Toxicology and Chemistry for continued

excellence in research and education. In 2002 he received the SETAC/Menzie-Curra Environmental Education Award from for his many

activities in environmental education, including hi undergraduate and graduate training. Dr. Giesy was selected as the International Man

of the Year-Environmental Toxicology in 1993 and received the QUINTESSENCE Award: Excellence in Environmental

Contamination & Toxicology for a paper published in 1994.

Prof. Giesy received the Distinguished Alumni Award from Alma College in

In 2003 Prof. Giesy received the Sir E.W. Russell Award in the Sciences from the British Soil Science Society. Prof. Giesy was a

member of the Boards of Directors of the International Association for Sediment and Water Science and the International Association of

Great Lakes Research. Prof. Giesy was president of the Michigan State University chapter of Sigma Xi The Research Society in 1994.

Prof. Giesy has served on the Board of Directors of the Society of Environmental Toxicology and Chemistry (SETAC) from 1986 until 1992

and as President of the Great Lakes Regional chapter in 1984 and of the international SETAC organization in 1990-1991. He was

Chairman of the Board of Directors of the SETAC Foundation for Environmental Education in 1992-93 and Vice President from 1993-

Prof. Giesy is a major donor to and sponsor of Michigan State University and Alma College. At Alma College he has been a

member of the Alumni Board and President of the Alumni Organization in 1995-96 and a member of the Board of Directors from 1994-97.

Prof. Giesy is listed in 38 biographical listings, including Who's Who in the World.

atrazine slides https://www.msu.edu/~giesy/Projects/Presentations/AZ-SS-XLLAB-03.pdf

• Thanks to L. Holden, L. Du Preez, B.

Sielken.

• This research was facilitated by the

Atrazine Endocrine Ecological Risk

Assessment Panel (ECORISK, Inc.) and

sponsored by Syngenta Crop Protection.

Other Recent Studies to be

Presented at SETAC

• Du Preez, LH.

Exposure characterization and responses to

field exposures of

Xenopus laevis

to atrazine and related

triazines in South African corn

growing regions. Sunday,

11/17 (P001)

• Coady, K.K.

Effects of atrazine on developing

Xenopus

laevis

: Potential endocrine di

sruption. Sunday, 11/17

(P093)

• Villeneuve, D.L.

Aromatase activity in tissues from adult

Xenopus laevis e

xposed to atrazine. S

unday, 11/17 (P086

Smith, Ernest E. -

Texas Tech University

• DuPreez, Louis -

Potchefstroom University

• Solomon, Keith R. -

University of Guelph

• Gentles, Angella B. -

Texas Tech University

• Tandler, Bernard A. -

Case Western Reserve

University

• Carr, James A. -

Texas Tech University

• Kendall, Ronald J. -

Texas Tech University

• Giesy, John P. -

Michigan State University

• Gross Timothy S. -

University of Florida

• Van Der Kraak Glen -

University of Guelph

Interactions between aryl hydrocarbon receptor (AhR) and hypoxia signaling pathways M Nie, AL Blankenship, JP Giesy Environmental toxicology and pharmacology 10 (1), 17-27	58		2001
Genetic and proteomic evidence for roles of Drosophila SUMO in cell cycle control, Ras signaling, and early pattern formation M Nie, Y Xie, JA Loo, AJ Courey PloS one 4 (6), e5905	51		2009
Oxygen uptake in bullfrog tadpoles (Rana catesbeiana) WC Crowder, M Nie, GR Ultsch Journal of Experimental Zoology 280 (2), 121-134	46		1998
Oxidative stress in liver and brain of the hatchling chicken (< i> Gallus domesticus) following in ovo injection with TCDD K Hilscherova, AL Blankenship, M Nie, KK Coady, BL Upham, JE Trosko, ... Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology ...	42		2003
Mechanisms of TCDD-induced abnormalities and embryo lethality in white leghorn chickens AL Blankenship, K Hilscherova, M Nie, KK Coady, SA Villalobos, ... Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology ...	34		2003
Dissolved oxygen, temperature, and habitat selection by bullfrog (Rana catesbeiana) tadpoles M Nie, JD Crim, GR Ultsch Copeia, 153-162	25		1999
DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes J Prudden, JJP Perry, M Nie, AA Vashisht, AS Arvai, C Hitomi, G Guenther, ... Molecular and cellular biology 31 (11), 2299-2310	21		2011
Antagonistic regulation of Yan nuclear export by Mae and Crm1 may increase the stringency of the Ras response H Song, M Nie, F Qiao, JU Bowie, AJ Courey Genes & development 19 (15), 1767-1772	19		2005
Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions M Nie, A Aslanian, J Prudden, J Heideker, AA Vashisht, JA Wohlschlegel, ... Journal of Biological Chemistry 287 (35), 29610-29619	14		2012
Different modes and potencies of translational repression by sequence-specific RNA–protein interaction at the 5′-UTR M Nie, H Htun Nucleic acids research 34 (19), 5528-5540	13		2006
Influences of temperature and oxygen upon habitat selection by bullfrog tadpoles and three species of freshwater fishes in two Alabama strip mine ponds GR Ultsch, SA Reese, M Nie, JD Crim, WH Smith, CM LeBerte Hydrobiologia 416, 149-162	12		1999
Oxidative stress in laboratory-incubated double-crested cormorant eggs collected from the Great Lakes K Hilscherova, A Blankenship, K Kannan, M Nie, LL Williams, K Coady, ... Archives of environmental contamination and toxicology 45 (4), 533-546	8		2003
A SUMO–Groucho Q domain fusion protein: Characterization and in vivo Ulp1-mediated cleavage D Kuo, M Nie, P De Hoff, M Chambers, M Phillips, AM Hirsch, AJ Courey Protein expression and purification 76 (1), 65-71	5		2011
Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 by SUMO and ubiquitin in STUbL-mediated genome stability functions. M Nie, A Aslanian, J Prudden, J Heideker, AA Vashisht, JA Wohlschlegel, ... Journal of Biological Chemistry	1		2012
RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response LM Groocock, M Nie, J Prudden, D Moiani, T Wang, A Cheltsov, ... EMBO reports 15 (5), 601-608			2014
The roles of SUMO in fly development MI Nie ProQuest			2008
Monitoring protein-RNA interaction in mammalian cells by translational repression M Nie, SM Betancourt, H Htun MOLECULAR BIOLOGY OF THE CELL 13, 523A-523A			2002
Interaction Between Aryl Hydrocarbon Receptor (AhR) and Hypoxia Signaling Pathways: A Potential Mechanism for TCDD Toxicity M Nie Michigan State University. Department of Zoology			1999
PloS one Volume: 4 ISSN: 1932-6203 ISO Abbreviation: PLoS ONE Publication Date: 2009 JC Moraes, A Coope, J Morari, DE Cintra, EA Roman, JR Pauli, ... Detail:
JG Prieto and AI Álvarez V Bruggeman, Q Swennen, B De Ketelaere, O Onagbesan, K Tona, ...	JG Prieto and AI Álvarez V Bruggeman, Q Swennen, B De Ketelaere, O Onagbesan, K Tona, ...	JG Prieto and AI Álvarez V Bruggeman, Q Swennen, B De Ketelaere, O Onagbesan, K Tona, ...	JG Prieto and AI Álvarez V Bruggeman, Q Swennen, B De Ketelaere, O Onagbesan, K Tona, ...

wall syn basel:

Richard A Brain (3)

Syngenta

Ronald J. Kendall

Ronald J. Kendall (3)

Texas Tech University

Alan Hosmer

Alan Hosmer (2)

Syngenta

Todd Alan Anderson

Todd Alan Anderson (2)

Texas Tech University

Michael Winchell

Michael Winchell (1)

Stone Environmental Inc

##### Richard A Brain (3)

Syngenta

Michael Winchell (1)

Stone Environmental Inc

Article: Recovery of duckweed from time-varying exposure to atrazine

Cited in 11 publications:

Baylor

Recovery of Terrestrial Plants in Vegetative Vigor and Seedling Emergence Tests from Exposure to Atrazine

Richard A Brain, James Hoberg

Effects of pulsed atrazine exposures on autotrophic community structure, biomass, and production in field-based stream...

Ryan S King, Richard A Brain, Jeffrey A Back, Christopher Becker, Moncie V Wright, Valerie Toteu Djomte, W Casan Scott, Steven R Virgil, Bryan W Brooks, Alan J Hosmer, C Kevin Chambliss

Growth Recovery of Lemna gibba and Lemna minor Following a 7-Day Exposure to the Herbicide Diuron

Mitchell Burns, Mark L Hanson, Ryan S Prosser, Angus N Crossan, Ivan R Kennedy

Article: Influence of light intensity on the toxicity of atrazine to the submerged freshwater aquatic macrophyte Elodea canadensis

Cited in 4 publications:

Evaluation of the side effects of poly(epsilon-caprolactone) nanocapsules containing atrazine toward maize plants

Halley C Oliveira, Renata Stolf-Moreira, Cláudia B R Martinez, Gustavo F M Sousa, Renato Grillo, Marcelo B de Jesus, Leonardo F Fraceto

Effects of different light intensities on the toxicities of atrazine and paraquat to algae

C. Liu, W. Wu, J. Li, X. Liang, K. Guo, F. Ge, J. Zhou

Nanoencapsulation Enhances the Post-Emergence Herbicidal Activity of Atrazine against Mustard Plants

Halley Caixeta Oliveira, Renata Stolf-Moreira, Cláudia Bueno Reis Martinez, Renato Grillo, Marcelo Bispo de Jesus, Leonardo Fernandes Fraceto

Source

Article: European starling nestling response to chlorpyrifos exposure in a corn agroecosystem

Cited in 2 publications:

Chlorpyrifos: Ecotoxicological Risk Assessment for Birds and Mammals in Corn Agroecosystems

K. R. Solomon, J. P. Giesy, R. J. Kendall, L. B. Best, J. R. Coats, K. R. Dixon, M. J. Hooper, E. E. Kenaga, S. T. McMurry

Accumulation of DDT and mercury in prothonotary warblers (Protonotaria citrea) foraging in a heterogeneously...

K D Reynolds, T R Rainwater, E J Scollon, S S Sathe, B M Adair, K R Dixon,