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Spike protein (Peplomer)
Prefusion and postfusion conformations
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Spike protein (Peplomer)
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Antibodies that recognize spike proteins in the prefusion shape are much more effective at preventing infection than antibodies that recognize spike proteins in the postfusion shape.
S-2P (2P)
Working alongside Jason McLellan, a structural biologist, they discovered that "adding two prolines to a key joint of a vaccine's spike protein could stabilize the structure's prefusion shape". Later, this method would be applied to the COVID-19 vaccine.