The History of Terrorism
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Spike protein (Peplomer)
Prefusion and postfusion conformations
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1955-Today National Institute of Allergy and Infectious Diseases (NIAID)
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Jason McLellan
Prefusion and postfusion conformations
Spike protein (Peplomer)
Children
Antibodies that recognize spike proteins in the prefusion shape are much more effective at preventing infection than antibodies that recognize spike proteins in the postfusion shape.
At least three other vaccines use this modified spike protein: those from Pfizer and BioNTech, Johnson & Johnson and Janssen Pharmaceutica, and Novavax.
McLellan-along with his team members Daniel Wrapp and Nianshuang Wang, plus Barney Graham and Kizzmekia Corbett at NIAID's Vaccine Research Center-engineered the spike protein to stay in its initial shape so it can be recognized.
NIAID, DARPA, BARDA, Lonza and Moderna's mRNA-1273 COVID-19 vaccine