Chemotherapy

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Chemotherapy
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Parents

1943 Air raid on Bari
1945-? Sloan-Kettering Institute for Cancer Research
1946? Due to his casualty studies on mustard gas from an accident during the war in Italy, Rhoads became interested in its potential for cancer treatment.
Alfred Gilman Sr.
Antineoplastic drugs
Cancer treatmemts
Cancer treatments
Cornelius P. Rhoads
Father of modern chemotherapy
Its (Mechlorethamine or Mustargen) success in clinical trials during the war years was the basis for the development of the field of anti-cancer chemotherapy.
Louis S. Goodman
Occupational safety and health
Oncology
Rhoads also became interested in total body irradiation, which led to early work on chemotherapy.
Sidney Farber
Sulfur mustard (mustard gas)
Total body irradiation (TBI)

Children

1940? Nearly eighty years ago, the faculty at Yale School of Medicine pioneered the modern concepts of chemotherapy by administering the very first anticancer agent, nitrogen mustard, to a patient with cancer.
1943? Alfred Gilman and Louis S. Goodman are the two men who suggested that mustard gas could have a dual purpose the second being chemotherapy.
1943? Shortly after publishing the first edition of his textbook, Gilman became section chief of pharmacology at the US Army's Edgewood Arsenal.
1943? Still affiliated with Yale, where Dean Milton C. Winternitz had recently signed a government contract with the Office of Scientific Research and Development to investigate agents of chemical warfare, ...
1955-? Second-Generation Chemotherapy
1994 What is the truth about HIV, AIDS? Dr Robert Willner Injects HIV into himself on TV
2000 Following the World Health Organization's (WHO) Millennium Development Goals in 2000, Hotez, along with Drs. Alan Fenwick and David Molyneux, led a global effort to rename diseases then being termed simply "other diseases," as "neglected tropical diseases" (NTDs), and promoting the use of therapeutic/preventive chemotherapy through a combination of drugs called the "rapid-impact package."[16] Hotez has advocated for increased efforts to control NTDs since 2005 through publications and speaking engagements, helping to gain increased awareness resulting in a decrease of prevalence and disease burden in many areas.[17]
2019 - A Brief History of Chemotherapy - Michelle Hamburger - Conners Clinic
Cisplatin
Combination chemotherapy
During Heller's tenure, the Institute (NCI) helped stimulate the development of several second-generation agents of chemotherapy.
Experimental cancer drugs
For the rest of his life, his research interest was in developing chemotherapy for cancer treatment, but he served primarily as an administrator and scientific director at Memorial and Sloan-Kettering.
James F. Holland
Mustard gas was used as a chemical warfare agent during World War I and was discovered to be a potent suppressor of hematopoiesis (blood production).
Rapid-impact package
Rational Drug Design
Research on mustard gas led to developments for its use in chemotherapy at Sloan Kettering.
The decision said Earl Brian, Reagan's secrectary of Health and Welfare represented "a callous disregard for public safety."
While working at Harvard Medical School on a research project funded by a grant from the American Cancer Society, he(Sidney Farber) carried out both the preclinical and clinical evaluation of aminopterin (synthesized by Yellapragada Subbarow).

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