2011 Ubiquitin Proteasome System programme

<p>May 05, 2015 09:57 PM</p>

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exclt 6 min video on&nbsp;Ub Proteasome System &nbsp;&nbsp;from 2011.</p>

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101K hits !!!</p>

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maintaining &nbsp;homeostasis/ balance... and at level of single cell.</p>

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QC for proteins... &nbsp;healthy balance of proteins.</p>

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UPS = Ub Proteasome System.</p>

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seek out and destroy &nbsp;bad proteins.</p>

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harmful proteins may build up...</p>

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Alz; &nbsp;viral, bacter, inflam diseases...</p>

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targeted for destruction... &nbsp;tagged with Ub. &nbsp;= ubiquitin.</p>

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must be primed by E1 &nbsp;activ &nbsp;enzyme.</p>

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then xfer to E2 conjug enz.</p>

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then to E3 &nbsp;ligase.</p>

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process is repeated to create polyub &nbsp;chain... clear signal to waste disposal to proteasome

to remove chain and chop up the the polypeptide.</p>

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