Ubiquitin

<p>May 05, 2015 09:31 PM</p>

<p>note: Nobel Prize in 2004 (split 3 ways) for
the discov of &nbsp;Ub-mediated protein degradation &nbsp;(see Protein QC Symposium at Stfd today).</p>

<p>UB = Ubiquitin &nbsp;is a small &nbsp;(8,500 dalton) &nbsp;regulatory protein &nbsp;; found in almost all tissues
(ubiquitously) of eukarytoic orgs.</p>

<p>produced by 4 genes in human genome.</p>

<p>Ubiquitination is a post-translational mod.</p>

<p>it can signal for their degradation via the proteasome;
alter their cellular location affect their activity
and promote or prevent protein interactions.</p>

<p>results of cascade is that Ub binds to lysine residues.</p>

<p>only poly-ubiqu on defined lysines mostly K48 and K29 leads to degradation with the proteasome...
the molecular kiss of death!!!</p>