NIH Pulls Plug on AIM-High Trial with Niacin
<p>Jul 13, 2011 06:21 PM
 
trial was halted 18 months early  cuz NIACIN showed NO benefit!!!
 
and small unexplained incr in ischemic stroke in the Niacin group.
 
some commentators thot it was the NAIL in the coffin for treating new lipid markers of CV risk, eg
TG or HDL.
 
Also listen to the video by Howard Weintraub... 9 mins... quite good...
 
He says, if ur LDL is abt 70 or so... the job is DONE!... There is nothing for HDL to do.
(but may be a difft story for pts with LDL of 110 eg).
 
He also notes that postmenopausal women (with high BP and glucos intol etc)  have high  
atheroscleros  despite high HDL  and  higher HDLs may be correlated  with MORE atheroscler
(he says its possible that their HDLs may be smaller, denser  ? less capable of transport)
 
My bottom line for me:   get  LDL as low as possible.
 
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