Hit to Lead
Intro
The way: Target validation (TV) → Assay development → High-throughput screening (HTS) → Hit to lead (H2L) → Lead optimization (LO) → Preclinical development → Clinical development
On average, only one in every 5,000 compounds that enters drug discovery to the stage of preclinical development becomes an approved drug.
Required steps after Hit confirmation
Structure modelling
use different docking models with the actual AF3 version
for Pf, NH125 see: NH125 Plasmodium Inhibitor - next steps
Real Structure +/- inhibitor
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Hit Expansion
Hit expansion : synthesis of analogs (hit expansion)