Forskolin, Cautions

<p>Cases of acute poisoning after the consumption of Coleus forskohlii products, possibly from contaminants, have been reported in Europe.</p>

<p><a href="http://www.medicalnewstoday.com/articles/25500.php" target="_blank">Acute Poisoning From Coleus Forskohlii Containing Products, Letter to Herbalists, UK. 2005</a>.</p>

<h2>Warning</h2>

<p>Forskolin may have a role in promoting cyst enlargement in patients with polycystic kidney disease. It is therefore recommended that these patients avoid the use of all preparations containing this compound.</p>

<p><a href="http://www.ncbi.nlm.nih.gov/pubmed/17251383" target="_blank">Identification of a forskolin-like molecule in human renal cysts.</a></p>

<h2>Adverse Effects</h2>

<p>Reported: Hypotension, tachycardia , headache</p>

<h2>Drug Interactions</h2>

<p><strong>Anti-hypertensives:</strong> Forskolin may have additive hypotensive effect with betablockers, vasodilators, calcium channel blockers, etc. .
<strong>Anticoagulants:</strong> Forskolin may cause bleeding due to additive platelet inhibition .
Forskolin can induce CYP3A gene expression and can potentially increase the metabolism of drugs that are substrates of related microsomal enzymes.</p>

<p><a href="http://www.ncbi.nlm.nih.gov/pubmed/15459237" target="_blank">Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway</a>.</p>