Astragalin

Astragalin belongs to the class of organic compounds known as flavonoid-3-o-glycosides. These are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to carbohydrate moiety at the C3-position. Astragalin is an extremely weak basic (essentially neutral) compound (based on its pKa). Outside of the human body, Astragalin is found, on average, in the highest concentration within a few different foods, such as yellow wax beans, green beans, and common beans and in a lower concentration in highbush blueberries, common grapes, and american cranberries. Astragalin has also been detected, but not quantified in, several different foods, such as sweet potato, parsley, bilberries, java plums, and docks. This could make astragalin a potential biomarker for the consumption of these foods. A kaempferol O-glucoside in which a glucosyl residue is attached at position 3 of kaempferol via a beta-glycosidic linkage.

Astragalin is found in alcoholic beverages. Astragalin is present in red wine. It is isolated from many plant species.Astragalin is a 3-O-glucoside of kaempferol. Astragalin is a chemical compound. It can be isolated from Phytolacca americana (the American pokeweed).

Articles/Studies

Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities

Anti-inflammatory

• Inhibitory effect of astragalin on expression of lipopolysaccharide-induced inflammatory mediators through NF-κB in macrophages
• Astragalin attenuates lipopolysaccharide-induced inflammatory responses by down-regulating NF-κB signaling pathway

Antioxidant

• Antioxidant effect of astragalin isolated from the leaves of *Morus alba* L. against free radical-induced oxidative hemolysis of human red blood cells
• Isolation and anti‐inflammatory effect of astragalin synthesized by enzymatic hydrolysis of tea seed extract

Cardiovascular

Cardioprotective Effects of Astragalin against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart

Diabetes

Diabetic Retinopathy : The effect of astragalin on the VEGF production of cultured Müller cells under high glucose conditions

Hormonal Effects

Astragalin, a Flavonoid from Morus alba (Mulberry) Increases Endogenous Estrogen and Progesterone by Inhibiting Ovarian Granulosa Cell Apoptosis in an Aged Rat Model of Menopause.

Immune System Effects

Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice

Oxidative Stress

Astragalin inhibits airway eotaxin-1 induction and epithelial apoptosis through modulating oxidative stress-responsive MAPK signaling

Respiratory System Effects

• Astragalin inhibits autophagy-associated airway epithelial fibrosis
• Astragalin Inhibits Allergic Inflammation and Airway Thickening in Ovalbumin-Challenged Mice

Other Effects

• Effect of astragalin on the activities of membrane bound enzymes on leadacetate toxicity in albino rats
• Effect of Astragalin on matrix secretion and beta 1 integrin mRNA expression in human mesangial cells.