Flavonoids

VIDEOS

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Physiological Effects of Flavonoids

Are Flavonoids like Terpenes in Marijuana?

Flavonoids are naturally occurring compounds, as secondary metabolites in the plants functioning as a plant’s physiological survival. They protect against fungal infections and UV radiation.

Flavonoids are synthesized by plants in response to infection. Active against bacteria and viruses, including HIV and respiratory syntactical virus (RSV)

Flavonoids universally have low absorption and are treated as xenobiotics, like toxins and drugs, to be eliminated from the body. Rutin from onions, for example, is about 7% absorbed and then metabolized. The benefits of flavonoids are mediated primarily through the principle of hormesis, which is the principle that a little of something bad for you can be good for you by improving your defenses

These include flavones, flavonals, flavonones, isoflavones, chalcones and aurones. Plants that are rich in flavonoids have been used as dyes. The fall colors, both the reds and yellows are flavonoids, always present in the leaves but hidden by chlorophyll until fall. Flavonoids are safe for people and animals but toxic to microorganisms. Plants produce them to protect themselves from disease. Many flavonoids are known to have antiviral and anti-inflammatory properties but they are especially valued as antioxidants to help protect the body from free radicals. Most flavonoids are wound healing.

These compounds are becoming established as major contributors to the cancer-prevention, anti-aging, and health-promoting effects of berries, fruits, vegetables, leafy greens, dark chocolate and coffee. All of the flavonoids have antioxidant activity to one degree or another.

Every green plant biosynthesizes a range of flavonoids, which serve as antioxidants to protect the plant's tissues against free radical damage. These compounds often occur in the form of water-soluble glycosides, intermixed with the more lipophilic aglycones. There are numerous subtypes, some widely distributed and others limited o a smaller number of species. The word root flav means yellow; some flavonoids (those first to be discovered, thus giving their name to the entire class) are yellow; but others are red, blue, purple, or even colorless. A number of those found in flowers emit light in the UV spectrum, making them especially visible to pollinators (bees) that can see wavelengths in the ultraviolet range.

The basic structure of a flavonoid consists of two phenolic rings, with varying numbers and kinds of substituents, joined in the middle by a central pyran ring. Hydroxylated, but as a C6-C3 unit linked to an aromatic ring.

In the subtypes, notice that the specific spelling tells us which functional groups and/or double bonds appear in the central 'C ring' of the molecule. Theflava –prefix means there is no double bond in the C ring itself. The flavo-prefix indicates there is a double bond between C2 and C3. You'll also notice various -ones and -ols in the names of the flavonoid subtypes, designating the presence of ketone or alcohol (hydroxyl) groups.

In general the flavonoids are anti-inflammatory, anticarcinogenic, antioxidant and cardioprotective. These activities are based on the fact that all of them contain phenolic rings and/or have a central structure resembling the stilbene core. (-Ganora)

They are generally diuretic and relieve cramping. They also affect the heart and circulatory system and strengthen capillaries. There are about 500 known flavonoids including vitamin C, E and P. The best way to get them is in fruits and vegetables. Fruits, especially wild berries, contain the highest amounts but they are found throughout the plant kingdom. - (Epel)

A recent prospective study reported that the specific flavonoid-rich foods associated with lower CVD mortality included apples, pears, grapefruit, strawberries, chocolate and bran.

Flavonoids are known to target prostaglandins in the late phase of acute inflammation and pain (Chakraborty et al., 2004).

The most used solvents for the extraction of flavonoids are ethanol, mixtures with water at different proportions, and natural deep eutectic solvents (NADES), which are based on their ability to solubilize moderately polar flavonoids with a relatively low cost and environmental impact. Extraction of Flavonoids From Natural Sources Using Modern Techniques

Articles/Studies

Alzheimer’s

The neuroprotective potentiality of flavonoids on Alzheimer's disease.

Anti-Inflammatory

Anti-inflammatory and anti-allergic potential of dietary flavonoids: A review.

Antiviral

Flavonoids: promising natural compounds against viral infections.
Inhibition of HIV activation in latently infected cells by flavonoid compounds
Roles of flavonoids against coronavirus infection. Up to now, there is no cure for COVID-19 and waiting for an efficacious vaccine, the development of"savage"protocols, based on"old"anti-inflammatory and anti-viral drugs represents a valid and alternative therapeutic approach. As an alternative or additional therapeutic/preventive option, different in silico and in vitro studies demonstrated that small natural molecules, belonging to polyphenol family, can interfere with various stages of coronavirus entry and replication cycle. Here, we reviewed the capacity of well-known (e.g. quercetin, baicalin, luteolin, hesperetin, gallocatechin gallate, epigallocatechin gallate) and uncommon (e.g. scutellarein, amentoflavone, papyriflavonol A) flavonoids, secondary metabolites widely present in plant tissues with antioxidant and anti-microbial functions, to inhibit key proteins involved in coronavirus infective cycle, such as PL, 3CL, NTPase/helicase. Due to their pleiotropic activities and lack of systemic toxicity, flavonoids and their derivative may represent target compounds to be tested in future clinical trials to enrich the drug arsenal against coronavirus infections.
Flavonoids and the CNS.

Antioxidant

Antioxidative and anti-adipogenesis activity of flavonoids

Cancer

Cardiovascular

Cognitive Function

These findings support a benefit of higher flavonoid intakes for maintaining cognitive function.

COVID-19

In silico evaluation of flavonoids as potential inhibitors of SARS-CoV-2 main nonstructural proteins.

Diabetes

Other Effects

(Images courtesy of Lisa Ganora)

Flavonoids

VIDEOS

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