NP - chaperone function

Chaperoning required for the genome

3D structures of the genome

NP in dsRNA melting

PMID: 35077748 /2022

see also: NP - RNA interaction

Questions

test if the inhibitors inhibit chaperone function / is the 117a effect over time a chaperone reaction? NO

Chaperon function - papers

pmid: 35935242 /2022 !! but no domains - unwinding activity at high conc

pmid: 34197802 molecular dynamics simulation RBD

pmid: 16979208 (Zuniga Enjuanes 2010 16979208) chaperone role in RNA folding (requires flexibility)

see: NP - RBD chaperone in RNA folding

Mechanism of chaperoning - collaboration with Ben schuler?

Holmstrom, E.D., Liu, Z., Nettels, D. et al. Disordered RNA chaperones can enhance nucleic acid folding via local charge screening. Nat Commun 10,2453 (2019). https://doi.org/10.1038/s41467-019-10356-0