report on stroke rehab
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Main Overview
Dysregulation of the Interferon Pathway
Antiviral Pathway Deregulation of Chronic Fatigue Syndrome Induces Nitric Oxide Production in Immune Cells That Precludes a Resolution of the Inflammatory Response
+4 White Blood Cells/Leukocytes/Mast Cells/Immune Cells
1 Irregularities in the Metabolism, Energy, Amino Acid, Nucleotide, nitrogen, hormone, nucleotide, oxidative stress metabolism
1 Abnormalities in bioenergetic function
Homeostasis is Dynamic Equilibrium within and without Internal and Environment
Stress
Continued Stress
Parents
+1 Anxiety Disorders
+2 Mood Disorders
+3 Neurological Dysfunction
1 pTBI-CF, TBI
Cognitive Dysfunction
Mental Health
Reduced Cortisol Maintains Stress Response (and Prevents Switch to Parasympathetic System)
Stress
Stress
Children
+1a Inflamation
Stimulation of Hypothalamic Mast Cells by Environmental Neuroimmune Pathogenic And stress triggers activates microglia leading to focal inflammation in the brain
Jumps
+5b Reduction in the capacity with which HPA axis hormones can restrain the immune system
1a) Stress Response System
1b) Stress Response System
3 Similarly, the HPA axis also interacts with various other glandular systems, among them those producing reproductive hormones, growth hormones, and thyroid hormones. Once activated, the stress response switches off the hormonal systems regulating growth, reproduction, metabolism, and immunity. Short term, the response is helpful, allowing us to divert biochemical resources to deal with the threat.
8 Chronic Immune Activation
Abnormal or Reduced Connectivity
ANS dysfunction/Dysautonomia
Brain Fog, Confusion, Sensory overstimulation, memory difficulties, pseudopsychopathy, High Effort in processing Planning Administrative Executive Function Planning Anxiety Stress Passive vs Proactive Shy Withdrawn Uncertain w social self esteem and anxiety etc Dysthymia etc
Cognition
Compensatory Cognition
Default State
Dysthemia
Emotional Stress/Trauma and OCD
Hypervigilance
negative feedback mediated by mineralocorticoid receptor (MR) and glucocorticoid receptor (GR)
Normally, cortisol also exerts a feedback effect to shut down the stress response after the threat has passed, acting upon the hypothalamus and causing it to stop producing CRH
OCD
OCD
Prolonged HPA Activation
Relatively Minor Physical or Psychological Stressors May Be Transduced into an Inflammatory Response by Triggering the Release of Inflammasomes and Subsequently Proinflammatory Cytokines
Stress Response 1
Stress Response 2
Stress response conditioning, sensitization
The stress circuit