Methylation
<p>From: 'Chronic Fatigue Syndrome, A Roadmap for Testing and Treatment' <a href="https://sites.google.com/site/cfstestingandtreatmentroadmap/home">https://sites.google.com/site/cfstestingandtreatmentroadmap/home</a>
Dr Rich Van Konynenburg believed that insufficient methylation is a factor behind ME/CFS, and recommends boosting methylation using a supplement regimen based on the treatment program developed by Dr Amy Yasko for autism. <br />
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The methylation protocol involves taking the following supplements daily: <b >vitamin B12 hydroxocobalamin</b>2000 mcg sublingual, <b >L-5-MTHF</b> 200 mcg, <b >folinic acid</b> 200 mcg, <b >lecithin</b> 1200 mg, and a <b >multivitamin/multimineral</b> tablet. Full details here: <a href="http://forums.phoenixrising.me/index.php?threads/revised-simplified-methylation-protocol-august-25-2012-revision.19050/" rel="nofollow" target="blank" >Revised Simplified Methylation Protocol</a> (this is the last revision Rich made to his protocol before his untimely death in 2012). Rich's study on 30 ME/CFS patients found that 27% of them achieved major improvements from methylation after three months.<a href="http://www.prohealth.com/library/showarticle.cfm?libid=16138" rel="nofollow" target="blank" >1</a> Patients found it took an average of 5 to 6 weeks before the protocol started to work. Some patients find this protocol does not work until they switch to the methylcobalamin form of vitamin B12 rather than using the hydroxocobalamin form.<br />
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Prof Carl-Gerhard Gottfries of the Gottfries Clinic in Sweden observed that vitamin B12 plus folate helps around 20 to 50% of ME/CFS or fibromyalgia patients with the MTHFR mutation. ME/CFS practitioners in the US observe similar results. To properly validate this observation, the Open Medicine Institute are currently running a three-year placebo-controlled, double-blinded study on the efficacy of vitamin B12 plus folate for treating ME/CFS.<a href="http://www.healthrising.org/blog/2013/12/05/bringing-relief-many-chronic-fatigue-syndrome-fibromyalgia-b-12-folate-crowdfund-trial-begins/" target="_blank" rel="nofollow" >1</a><br />
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The <a href="http://www.hdri-usa.com" rel="nofollow" target="blank" >Health Diagnostics and Research Institute</a> in New Jersey provide a test for methylation status, as do the <a href="http://www.europeanlaboratory.nl/" rel="nofollow" target="blank" >European Laboratory of Nutrients</a> (see their "amino acids analysis"). More info about methylation: <a href="http://phoenixrising.me/treating-cfs-chronic-fatigue-syndrome-me/treating-chronic-fatigue-syndrome-mecfs-glutathione-and-the-methylation-cycle" rel="nofollow" target="blank" >Glutathione and the Methylation Cycle</a>, <a href="http://me-pedia.org/wiki/Methylation_cycle_hypothesis" target="blank" rel="nofollow" >Methylation cycle hypothesis - MEpedia</a>.</p>