Normal Cognition

If the history, examination and initial cognitive screening suggest no significant change in cognitive (or behavioral) ability, then the individual would be classified as having “normal” cognition. This doesn’t mean normal in terms of a Bell curve. They could be far from the mean or median for a population of people of similar age. Normal in this sense just means there is no clear indication of any acquired cognitive difficulties.

People who notice cognitive decline that cannot be detected or confirmed using cognitive tests are said to have Subjective Cognitive Impairment (SCI). There is also a group of patients with only behavioral changes, but no demonstrable cognitive impairment evident on testing. These behavior-only individuals are sometimes classified as having Mild Behavioral Impairment (MBI). Some individuals with SCI and MBI will go on to have MCI or dementia, so they need to be followed with repeated assessments.

Currently, individuals with normal cognition are excluded from consideration for anti-amyloid therapy, though this could potentially change in the future.

Click the Exclude from Treatment link to see about next steps.