Positive for Amyloid

By “positive for amyloid,” I mean that the PET scan revealed a quantitative excess of amyloid in the brain, consistent with Alzheimer’s Disease, OR the spinal fluid test was suggestive of AD. There is no good reason to do both tests in my view.

Given that there are now two FDA-approved anti-amyloid therapies that have been shown to improve long-term functional and cognitive outcomes in MCI due to AD or mild AD, it is appropriate to Discuss Treatment Options with Anti-amyloid Agents at this stage in the algorithm.