P53

<span style=" font-size: 36.0pt; font-family: 'Arial Black'; mso-ascii-font-family: Arial Black; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mj-cs; mso-ascii-theme-font: major-latin; mso-fareast-theme-font: major-fareast; mso-bidi-theme-font: major-bidi; mso-color-index: 3; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text2; mso-style-textfill-fill-color: #FFCC00; mso-style-textfill-fill-alpha: 100.0%;">p53<span style=" font-size: 36.0pt; font-family: 宋体; mso-ascii-font-family: Arial Black; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mj-cs; mso-ascii-theme-font: major-latin; mso-fareast-theme-font: major-fareast; mso-bidi-theme-font: major-bidi; mso-color-index: 3; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text2; mso-style-textfill-fill-color: #FFCC00; mso-style-textfill-fill-alpha: 100.0%;">抑制肿瘤细胞通过磷酸戊糖途径生成<span style=" font-size: 36.0pt; font-family: 'Arial Black'; mso-ascii-font-family: Arial Black; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mj-cs; mso-ascii-theme-font: major-latin; mso-fareast-theme-font: major-fareast; mso-bidi-theme-font: major-bidi; mso-color-index: 3; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text2; mso-style-textfill-fill-color: #FFCC00; mso-style-textfill-fill-alpha: 100.0%;">5-<span style=" font-size: 36.0pt; font-family: 宋体; mso-ascii-font-family: Arial Black; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mj-cs; mso-ascii-theme-font: major-latin; mso-fareast-theme-font: major-fareast; mso-bidi-theme-font: major-bidi; mso-color-index: 3; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text2; mso-style-textfill-fill-color: #FFCC00; mso-style-textfill-fill-alpha: 100.0%;">磷酸核糖

<div style=" language: zh-CN; line-height: 90%; margin-top: 6.72pt; margin-bottom: 0pt; margin-left: .38in; text-indent: -.38in; text-align: left; direction: ltr; unicode-bidi: embed; vertical-align: baseline; mso-line-break-override: none; punctuation-wrap: hanging;"><img src="/9643bd92-d41f-5e92-b88d-b05ab3480c1d.tmp"/><span style=" font-size: 28.0pt; font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">来自中国科学技术大学、美国宾夕法尼亚大学和南京大学的研究人员在一项新研究中揭示了肿瘤抑制因子<span style=" font-size: 28.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">p53<span style=" font-size: 28.0pt; font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">在糖代谢中的作用机制，相关研究成果<span style=" font-size: 28.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">2011<span style=" font-size: 28.0pt; font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">年<span style=" font-size: 28.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">2<span style=" font-size: 28.0pt; font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">月<span style=" font-size: 28.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">20<span style=" font-size: 28.0pt; font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">日在线发表在国际著名学术期刊<span style=" font-size: 28.0pt; font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">《<span style=" font-size: 28.0pt; font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">自然细胞生物学（<span style=" font-size: 28.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">Nature Cell Biology<span style=" font-size: 28.0pt; font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">）上。<span style=" font-size: 28.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">Nature Cell Biology<span style=" font-size: 28.0pt; font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">并在同期以<span style=" font-size: 28.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">News and Views<span style=" font-size: 28.0pt; font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">的形式对这一论文发表了题为<span style=" font-size: 28.0pt; font-family: 'Times New Roman'; mso-ascii-font-family: Times New Roman; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">“<span style=" font-size: 28.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">p53 guards the metabolic pathway less travelled<span style=" font-size: 28.0pt; font-family: 'Times New Roman'; mso-ascii-font-family: Times New Roman; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">”<span style=" font-size: 28.0pt; font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">的长篇评论<span style=" font-size: 28.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">(<span style=" font-size: 28.0pt; font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">详细内容见<span style=" font-size: 28.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">word <span style=" font-size: 28.0pt; font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">文件<span style=" font-size: 28.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">)<span style=" font-size: 28.0pt; font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">。</div>

<p style=" language: zh-CN; line-height: 90%; margin-top: 6.72pt; margin-bottom: 0pt; margin-left: 0in; text-indent: 0in; text-align: left; direction: ltr; unicode-bidi: embed; vertical-align: baseline; mso-line-break-override: none; punctuation-wrap: hanging;"><span style=" font-size: 28.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">* <span style=" font-size: 28.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">p53<span style=" font-size: 28.0pt; font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">为重要的肿瘤抑制基因之一，人体有超过<span style=" font-size: 28.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">50%<span style=" font-size: 28.0pt; font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">以上的肿瘤出现<span style=" font-size: 28.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">p53<span style=" font-size: 28.0pt; font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-ascii-theme-font: minor-latin; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; mso-color-index: 1; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: white; mso-style-textfill-fill-alpha: 100.0%;">基因突变。