siRNA
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<img src="/75a4840f-a5fa-58c8-9481-179c3ddd645d.png"/></p>
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<span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">1. </span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">病毒基因、人工转入基因等外源性基因整合到宿主细胞基因组并利用宿主细胞进行转录时，常产生一些</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">dsRNA</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">。</span><u style=" text-underline: single;"><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">宿主细胞中的核酸内切酶</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">Dicer</span></u><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">将</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">dsRNA</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">切割成多个具有特定长度和结构的小片段</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">RNA</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">（大约</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">21</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">～</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">23 bp</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">），即</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">siRNA</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">。</span>
<span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">2. siRNA</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">在细胞内</span><u style=" text-underline: single;"><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">RNA</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">解旋酶</span></u><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">作用下解链成正义链和反义链，反义</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">siRNA</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">再与体内一些酶（包括内切酶、外切酶、解旋酶等）结合形成</span><u style=" text-underline: single;"><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">RNA</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">诱导的沉默复合物</span></u><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">（</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">RNA-induced silencing complex</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">，</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">RISC)</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">。</span>
<span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">3. RISC</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">具有核酸酶的功能，与外源性基因表达的</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">mRNA</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">的同源区进行特异性结合并在</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: red; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-color: red; mso-style-textfill-fill-alpha: 100.0%;">反义链互补结合的两端</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">切割</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">mRNA</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">，切割断裂</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">mRNA</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">随即降解，并诱发宿主细胞针对这些</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">mRNA</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">的降解反应。</span>
<span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">4. siRNA</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">不仅能引导</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">RISC</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">切割同源单链</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">mRNA</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">，而且可作为引物与靶</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">RNA</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">结合并在</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">RNA</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">聚合酶</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">(RNA-dependent RNA polymerase</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">，</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">RdRP</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">）作用下合成更多新的</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">dsRNA</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">，新合成的</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">dsRNA</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">再由</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">Dicer</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">切割产生大量的次级</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">siRNA</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">，从而使</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">RNAi</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">的作用进一步放大，最终将靶</span><span style=" font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">mRNA</span><span style=" font-family: 宋体; mso-ascii-font-family: Arial; mso-fareast-font-family: 宋体; mso-bidi-font-family: +mn-cs; mso-bidi-theme-font: minor-bidi; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">完全降解。</span>
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