lncRNA
<p style=" language: zh-CN; line-height: 150%; margin-top: 0pt; margin-bottom: 0pt; text-align: left; direction: ltr; unicode-bidi: embed; vertical-align: baseline; mso-line-break-override: restrictions; punctuation-wrap: simple;"><span style=" font-size: 20.0pt; font-family: 'Times New Roman'; mso-ascii-font-family: Times New Roman; mso-fareast-font-family: 宋体; mso-bidi-font-family: Times New Roman; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;"><span style=" mso-spacerun: yes;"> </span>长</span><span style=" font-size: 20.0pt; font-family: 宋体; mso-ascii-font-family: Times New Roman; mso-fareast-font-family: 宋体; mso-bidi-font-family: Times New Roman; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">链非编码</span><span style=" font-size: 20.0pt; font-family: 'Times New Roman'; mso-ascii-font-family: Times New Roman; mso-fareast-font-family: 宋体; mso-bidi-font-family: Times New Roman; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">RNA(lncRNA)</span><span style=" font-size: 20.0pt; font-family: 宋体; mso-ascii-font-family: Times New Roman; mso-fareast-font-family: 宋体; mso-bidi-font-family: Times New Roman; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">是一类转录本长度超过</span><span style=" font-size: 20.0pt; font-family: 'Times New Roman'; mso-ascii-font-family: Times New Roman; mso-fareast-font-family: 宋体; mso-bidi-font-family: Times New Roman; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">200nt</span><span style=" font-size: 20.0pt; font-family: 宋体; mso-ascii-font-family: Times New Roman; mso-fareast-font-family: 宋体; mso-bidi-font-family: Times New Roman; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">的</span><span style=" font-size: 20.0pt; font-family: 'Times New Roman'; mso-ascii-font-family: Times New Roman; mso-fareast-font-family: 宋体; mso-bidi-font-family: Times New Roman; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">RNA</span><span style=" font-size: 20.0pt; font-family: 宋体; mso-ascii-font-family: Times New Roman; mso-fareast-font-family: 宋体; mso-bidi-font-family: Times New Roman; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">分子，不编码蛋白，而是以</span><span style=" font-size: 20.0pt; font-family: 'Times New Roman'; mso-ascii-font-family: Times New Roman; mso-fareast-font-family: 宋体; mso-bidi-font-family: Times New Roman; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">RNA</span><span style=" font-size: 20.0pt; font-family: 宋体; mso-ascii-font-family: Times New Roman; mso-fareast-font-family: 宋体; mso-bidi-font-family: Times New Roman; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">的形式在多种层面上（表观遗传调控、转录调控以及转录后调控等）调控基因的表达水平。</span>
<span style=" font-size: 20.0pt; font-family: 'Times New Roman'; mso-ascii-font-family: Times New Roman; mso-fareast-font-family: 宋体; mso-bidi-font-family: Times New Roman; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;"><span style=" mso-spacerun: yes;"> </span>lncRNA</span><span style=" font-size: 20.0pt; font-family: 宋体; mso-ascii-font-family: Times New Roman; mso-fareast-font-family: 宋体; mso-bidi-font-family: Times New Roman; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">起初被认为是基因组转录的“噪音”，是</span><span style=" font-size: 20.0pt; font-family: 'Times New Roman'; mso-ascii-font-family: Times New Roman; mso-fareast-font-family: 宋体; mso-bidi-font-family: Times New Roman; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">RNA</span><span style=" font-size: 20.0pt; font-family: 宋体; mso-ascii-font-family: Times New Roman; mso-fareast-font-family: 宋体; mso-bidi-font-family: Times New Roman; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">聚合酶</span><span style=" font-size: 20.0pt; font-family: 'Times New Roman'; mso-ascii-font-family: Times New Roman; mso-fareast-font-family: 宋体; mso-bidi-font-family: Times New Roman; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">II</span><span style=" font-size: 20.0pt; font-family: 宋体; mso-ascii-font-family: Times New Roman; mso-fareast-font-family: 宋体; mso-bidi-font-family: Times New Roman; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">转录的副产物，不具有生物学功能。近年来的研究却发现，</span><span style=" font-size: 20.0pt; font-family: 'Times New Roman'; mso-ascii-font-family: Times New Roman; mso-fareast-font-family: 宋体; mso-bidi-font-family: Times New Roman; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">lncRNA</span><span style=" font-size: 20.0pt; font-family: 宋体; mso-ascii-font-family: Times New Roman; mso-fareast-font-family: 宋体; mso-bidi-font-family: Times New Roman; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">参与了</span><span style=" font-size: 20.0pt; font-family: 'Times New Roman'; mso-ascii-font-family: Times New Roman; mso-fareast-font-family: 宋体; mso-bidi-font-family: Times New Roman; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">X</span><span style=" font-size: 20.0pt; font-family: 宋体; mso-ascii-font-family: Times New Roman; mso-fareast-font-family: 宋体; mso-bidi-font-family: Times New Roman; color: #003366; mso-color-index: 1; mso-font-kerning: 12.0pt; language: zh-CN; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: #003366; mso-style-textfill-fill-alpha: 100.0%;">染色体沉默，基因组印记以及染色质修饰，转录激活，转录干扰，核内运输等多种重要的调控过程。</span></p>