Melatonin Studies
- Melatonin in humans
- Dietary Chronobiotics: Polyphenols and Plant Melatonin
- The absolute bioavailability of oral melatonin.
- Guidelines for prescribing melatonin.
- Melatonin as an endogenous regulator of diseases: The role of autophagy.
- Melatonin content of supplements varies widely, study finds (https://www.sciencedaily.com/releases/2017/02/170214162728.htm)
- Cellular mechanisms of melatonin: Insight from neurodegenerative diseases.
- Melatonin counteracts drought induced oxidative damage and stimulates growth, productivity and fruit quality properties of tomato plants.
- Daytime exposure to blue light alters cardiovascular circadian rhythms, electrolyte excretion and melatonin production.
- Melatonin-driven NLRP3 inflammation inhibition.
Aging
- Melatonin may provide a therapeutically beneficial role in the anti-aging processes
- Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
- Melatonin supplementation may enhance immunity in aged individuals by upregulating immunosenescence indices.
Anti-Viral
- Melatonin demonstrates an inhibitory role in HSV-1 replication.
- Effects of melatonin alone or associated with acyclovir on the suppressive treatment of recurrent genital herpes.
Cancer
- Therapeutic strategies of melatonin in cancer patients: a systematic review and meta-analysis
- Melatonin is a promising in vitro anti-tumour agent.
- Sleep Aid, Cancer Crusader? Mounting Data Suggests Melatonin Belongs in Oncology
- Melatonin: A Molecule for Reducing **Breast Cancer** Risk
- The effect of melatonin on increasing the health related quality of life in **non-metastatic breast cancer** patients.
- Melatonin decreases **breast cancer** metastasis by modulating Rho-associated kinase protein-1 expression
- Physiological melatonin inhibition of human **breast cancer** cell growth in vitro: evidence for a glutathione-mediated pathway.
- Inhibition of procarcinogen-bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin.
- Expression of melatonin receptor (MT1) and interaction between melatonin and estrogen in **endometrial cancer** cell line.
- Melatonin mitigates the progression of chemically induced **hepatocellular carcinoma**.
- Five years survival in metastatic **non-small cell lung cancer** patients treated with chemotherapy alone or chemotherapy and melatonin: a randomized trial.
- Neuroimmunomodulation in medical oncology: application of psychoneuroimmunology with subcutaneous low-dose IL-2 and the pineal hormone melatonin in patients with untreatable **metastatic solid tumors
- Direct antiproliferative effects of melatonin on two metastatic cell sublines of mouse **melanoma** (B18BL6 and PG19).
- Melatonin enhances the sensitivity of **colorectal cancer** cells to 5-fluorouracil.
- Inhibition of androgen-sensitive LNCaP **prostate cancer** growth in vivo by melatonin: association of antiproliferative action of the pineal hormone with mt1 receptor protein expression
- Melatonin and **prostate cancer**: anti-tumor roles and therapeutic application.
- A randomized study with the pineal hormone melatonin versus supportive care alone in patients with **brain metastases** due to solid neoplasms.
- Melatonin inhibits **Glioblastoma stem-like cells**.
- Melatonin as a novel selective ATF-6 inhibitor can sensitize human **hepatoma cells** to ER stress inducing apoptosis.
- Increase in motility and invasiveness of **MCF7 cancer cells induced by nicotine** is abolished by melatonin through inhibition of ERK phosphorylation.
- Melatonin represses **oral squamous cell carcinoma metastasis** by inhibiting tumor-associated neutrophils
- Melatonin inhibits growth and metastasis of MDA-MB-231 **breast cancer** cells.
- Melatonin Inhibits **gastric cancer** cell proliferation by suppressing exosome miR-27b-3p expression.
- Potential of melatonin to reverse epigenetic aberrations in **oral cancer**.
- The hypnotic efficacy of oral melatonin 3 mg was better than oral L-theanine 200 mg in cancer patients having insomnia.
- Melatonin changes energy metabolism and reduces oncogenic signaling in **ovarian cancer cells**.
Cardiovascular Effects
- Oral melatonin reduces blood coagulation activity: a placebo-controlled study in healthy young men.
- Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: a 24-hour study
- Role of exogenous melatonin on adriamycin-induced changes in the rat heart.
- A review of melatonins protection against age-related cardiac pathology.
- Melatonin might help control weight gain and prevent heart disease associated with obesity (https://www.sciencedaily.com/releases/2011/04/110428092501.htm)
- Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: a 24-hour study.
- Melatonin supplementation regressed vascular wall remodeling and restored its functional capacity. in obesity
- Melatonin as a therapeutic agent for alleviating endothelial dysfunction in cardiovascular diseases: Emphasis on oxidative stress.
- Melatonin supplementation in heart failure with reduced ejection fraction might improve endothelial function.
Cognitive
COVID-19
- Cleveland Clinic: Melatonin May Be a Viable Treatment for COVID-19
- Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vessels.
- Melatonin: a ferroptosis inhibitor with potential therapeutic efficacy for the post-COVID-19 trajectory of accelerated brain aging and neurodegeneration.
Depression
Diabetes
- Melatonin treatment could be a novel therapeutic strategy for diabetic retinopathy.
- Melatonin relieves diabetic complications and regenerates pancreatic beta cells.
- Melatonin alleviates renal injury in diabetic rats by regulating autophagy.
- Protective effect of melatonin against metabolic disorders and neuropsychiatric injuries in type 2 diabetes mellitus.
- Melatonin increases AKT and SOD gene and protein expressions in diabetic rats.
Gastrointestinal
- Melatonin attenuates bisphenol A-induced colon injury.
- Melatonin pretreatment improves endometrial regenerative cell-mediated therapeutic effects in experimental colitis.
Insulin Sensitivity
Melatonin improves glucose homeostasis and insulin sensitivity by mitigating inflammation.
Immune System
- Melatonin: Buffering the immune system
- Melatonin protects CD4+ T cells from activation-induced cell death by blocking NFAT-mediated CD95 ligand upregulation.
Liver Effects
The therapeutic effects of melatonin on cholestatic liver injury have received widespread attention recently
- Melatonin alleviated the distortion of normal hepatic architecture, lowering the incidence of preneoplastic and neoplastic lesions.
- Melatonin protects against lipid-induced mitochondrial dysfunction in hepatocytes and inhibits stellate cell activation during hepatic fibrosis.
- iTRAQ-based quantitative proteomics analysis of the hepatoprotective effect of melatonin on ANIT-induced cholestasis in rats.
- Melatonin attenuates cholestatic liver injury via inhibition of the inflammatory response.
- Melatonin protects against methotrexate hepatotoxicity.Melatonin inhibits VEGF-induced endothelial progenitor cell angiogenesis in neovascular age-related macular degeneration.
- Melatonin ameliorates hepatic fibrosis via the melatonin receptor 2-mediated upregulation of BMAL1 and anti-oxidative enzymes.
Lung Injury
Melatonin attenuates sepsis-induced acute lung injury via inhibiting excessive mitophagy.
Macular Degeneration
Memory
Finally, a Supplement That Actually Boosts Memory – Many Already Take It for Better Sleep
Mental Health
- Coadministration of melatonin with olanzapine in adolescents with bipolar disorder could reduce the sharp weight gain side effect.
- Melatonin for Schizophrenia
- Role of Melatonin in Schizophrenia
- Benefits of the neurogenic potential of melatonin for treating neurological and neuropsychiatric disorders.
Migraine
Muscle
Melatonin to be a decisive mitochondrial function-fate regulator in skeletal muscle.
Neuroprotective
- Melatonin treatment alleviates spinal cord injury-induced gut dysbiosis in mice.
- This review discusses and evaluates the neuroprotective functions of melatonin in Alzheimer's disease pathogenesis
- Melatonin Prevents the Harmful Effects of Obesity on the Brain, Including at the Behavioral Level.
- Melatonin protects against Aβ-induced neurotoxicity in primary neurons via miR-132/PTEN/AKT/FOXO3a pathway
- Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage.
- Melatonin a Potent therapeutic for stroke and stroke-related dementia.
Osteoarthritis
Pain
- Melatonin Suppresses Neuropathic Pain via MT2-Dependent and -Independent Pathways in Dorsal Root Ganglia Neurons of Mice
- Melatonin as preemptive analgesic for intraoperative pain.
- Melatonin was found to be effective in many of these cases as an anxiolytic and analgesic agent, indicating its clinical application.
- Exogenous melatonin in the treatment of pain: a systematic review and meta-analysis
Radiation Protection
- Antioxidative effects of melatonin in protection against cellular damage caused by ionizing radiation.
- Modulation of Radiation-induced Base Excision Repair Pathway Gene Expression by Melatonin
- Melatonin Ameliorates Radiation-Induced Oxidative Stress at Targeted and Nontargeted Lung Tissue
Renoprotective
Melatonin ameliorates renal dysfunction in glyphosate- and hard water-treated mice.
Sleep
- Melatonin for the promotion of sleep in adults in the intensive care unit.
- Use of melatonin for sleep and circadian rhythm disorders.
- Effect of melatonin administration on sleep, behavioral disorders and hypnotic drug discontinuation in the elderly: a randomized, double-blind, placebo-controlled study.
- Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of sleep and next-day alertness outcomes.
- Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta analysis
- Melatonin versus trazodone for the treatment of new onset insomnia.
Other Effects
- Melatonin reduces hypoxic-ischaemic induced autophagy and apoptosis.
- This study shows that melatonin has a protective effect on the glyphosate exposed E. sinensis.
- Melatonin modulates aromatase activity and expression in endothelial cells
- Melatonin affects voltage-dependent calcium and potassium currents in MCF-7 cell line cultured either in growth or differentiation medium.
- Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: a review of the evidence
- Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study.
- Melatonin rescued the apoptotic changes via the intrinsic pathway.
- Melatonin derivatives anti-oxidant and protective effects on human gingival fibroblasts.
- Melatonin attenuates lung ischaemia-reperfusion injury via inhibition of oxidative stress and inflammation. -
- Evaluating The Effect of Melatonin on HAS2, and PGR expression, as well as Cumulus Expansion, and Fertility Potential in Mice.
- The effects of melatonin and curcumin on the expression of SIRT2, Bcl-2 and Bax in the hippocampus of adult rats.
- Melatonin alleviates neonatal necrotizing enterocolitis.
- Melatonin mitigates rotenone-induced oxidative stress and mitochondrial dysfunction.
- The effects of melatonin supplementation on professional football player performance.
- The co-treatment of melatonin and arsenic reversed the changes caused by arsenic.