Fetuin

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Fetuins are blood proteins that are made in the liver and secreted into the bloodstream. They are a large group of binding proteins that mediate the transport and availability of a wide variety of cargo substances in the bloodstream.

Fetuin is an acidic blood protein that is considered to be an inhibitory protein that helps prevent ectopic calcifications in soft tissues, plaques, and stones.

Fetuins are glycoproteins that contain sialylated N-linked and O-linked glycans. They can be used as a positive control for endoglycosidase enzymes that cleave both N-linked and O-linked carbohydrates.

Fetuin-A is a major carrier protein of free fatty acids in the circulation. Increased fetuin-A concentrations are associated with impaired glucose tolerance with or without nonalcoholic fatty liver disease