Feverfew, Studies

Feverfew (Tanacetum parthenium L.): A systematic review.

Antiprotozoal

• Trypanosoma cruzi: antiprotozoal activity of parthenolide obtained from Tanacetum parthenium (L.) Schultz Bip. (Asteraceae, Compositae) against epimastigote and amastigote forms.

Cancer

• Parthenin, a compound found within feverfew, is cytotoxic to mastocytoma, leukemia and rhabdomyosarcoma cells.
• Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer

Cardiovascular

• A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro.
• Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes.

Cystic Fibrosis

• Parthenolide (from Feverfew) may down-regulate excessive inflammation in Cystic Fibrosis

HSV-1

Extracts from the aerial parts of Tanacetum parthenium has in vivo anti-HSV-1 activity and is safe for oral and topical application.

Kidney Effects

• Parthenolide (a compound from Feverfew) prevent proteinura and renal lesions.
• Feverfew extract had potent nephroprotective effects against oxygen free radicals produced through carbon tetrachloride metabolism.

Migraine

• A supercritical extract of feverfew is safe and efficacious in migraine prevention.
• Feverfew and white willow are well-tolerated and effective in migraine prevention.
• Elimination of 'dietary triggers' and the inclusion of a number of natural substances may prevent migraines.
• The therapeutic activity of feverfew on migraines and epilepsy may be due to its GABA-benzodiazepine modulatory effects.
• Feverfew modulates genes in human monocytic cells, including CCL2, which may explain its antimigraine activity.
• Efficacy and safety of 6.25 mg t.i.d. feverfew CO2-extract (MIG-99) in migraine prevention – A randomized, double-blind, multicentre, placebo-controlled study.
• A double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic M) in the treatment of migraine.
• The combined effect of acupuncture and Tanacetum parthenium on quality of life in women with headache: randomised study.
• Efficacy of feverfew as prophylactic treatment of migraine
• Randomised double-blind placebo-controlled trial of feverfew in migraine prevention.

Radiation Protection

• Parthenolide-depleted feverfew (Tanacetum parthenium) protects skin from UV irradiation and external aggression

Rheumatoid Arthritis

• Feverfew in rheumatoid arthritis: a double blind, placebo controlled study.  (no benefit)