Ligstroside

Ligstroside is a phenolic compound found in olive trees. It is a plant metabolite and antineoplastic agent. Ligstroside has anti-inflammatory properties. It can inhibit the COX-1 enzyme, which is involved in arachidonate cascade metabolism. Ligstroside can also increase the expression of SIRT1, CREB1, complex I, and GPx1.

Ligstroside aglycone (LA) is a polyphenol found in extra virgin olive oil. It is also known as p-HPEA-Elenolic acid. LA has antioxidant properties. It can prevent inflammation by regulating signaling pathways in macrophages. Ligstroside aglycone may be a nutraceutical for treating osteoarthritis.

ARTICLES/STUDIES

• Olea europaea L-derived secoiridoids: Beneficial health effects and potential therapeutic approaches.
• Potential Protective Role Exerted by Secoiridoids from Olea europaea L. in Cancer, Cardiovascular, Neurodegenerative, Aging-Related, and Immunoinflammatory Diseases.

Alzheimer’s

Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing.

Anti-inflammatory

Ligstroside aglycon, an extra virgin olive oil secoiridoid, prevents inflammation by regulation of MAPKs, JAK/STAT, NF-kappaB, Nrf2/HO-1, and NLRP3 inflammasome signaling pathways in LPS-stimulated murine peritoneal macrophages.

Antioxidant

Effect of olive leaf phytochemicals on the anti-acetylcholinesterase, anti-cyclooxygenase-2 and ferric reducing antioxidant capacity.

Cancer

• Potential Uses of Olive Oil Secoiridoids for the Prevention and Treatment of Cancer: A Narrative Review of Preclinical Studies.
• The Olive Oil Monophenolic Secoiridoid Ligstroside Aglycone Suppresses Melanoma Progression by Targeting the BRAF Signaling Pathway.
• Anti-Proliferative Effects of an Extra-Virgin Olive Oil Extract Enriched in Ligstroside Aglycone and Oleocanthal on Human Liver Cancer Cell Lines.

Metabolic Syndrome

The clinical impact of an extra virgin olive oil enriched mediterranean diet on metabolic syndrome: Lights and shadows of a nutraceutical approach.

Osteoarthritis

Osteoarthritis treatment with a novel nutraceutical acetylated ligstroside aglycone, a chemically modified extra-virgin olive oil polyphenol.