Curcumin, cautions

There is a potential for drug interactions because curcumin inhibits cytochrome P-450 isozymes. (BG)  (Cytochrome P450 enzymes are found in and on the smooth endoplasmic reticulum of liver and other cells and are responsible for a large number of drug biotransformation reactions.)

Curcumin could inhibit CYP2C9 and CYP3A4 indicating the potency of stopping the stop oxidation of steroids, fatty acids, and xenobiotics as well as for hormone synthesis and breakdown

Curcuminmay result in an increased risk of bleeding if used with anticoagulants or NSAIDs; avoid concurrent use.

Curcuminmay decrease the effectiveness of immunosuppressants; avoid concurrent use.

In terms of energetics, curcumin / turmeric is very dry so avoid in those with dry signs/constitution/syndromes...OR, combine with equal parts of Licorice (potent anti-inflammatory) or Marshmallow.