Myokines
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Videos
Myokines Explained in 5 minutes
Activate Your Myokines
Myokines - Why heavy exercise makes bones and muscles stronger.
Exercise and inter-tissue communication - Dr Martin Whitham
Contract Your Muscles and Activate Your Myokines: Focus on IL-6
Bente Klarlund - Exercise as Medicine and the role of myokines: a translational perspective
A myokine is one of several hundred cytokines or other small proteins (5–20 kDa) and proteoglycan peptides that are produced and released by skeletal muscle cells (muscle fibers) in response to muscular contractions. They have autocrine, paracrine and/or endocrine effects; their systemic effects occur at picomolar concentrations.
Receptors for myokines are found on muscle, fat, liver, pancreas, bone, heart, immune, and brain cells. The location of these receptors reflects the fact that myokines have multiple functions. Foremost, they are involved in exercise-associated metabolic changes, as well as in the metabolic changes following training adaptation.They also participate in tissue regeneration and repair, maintenance of healthy bodily functioning, immunomodulation; and cell signaling, expression and differentiation.