Atrophic Gastritis

See also Gastric Atrophy and Chronic atrophic gastritis

Atrophic gastritis is a process of chronic inflammation of the gastric mucosa of the stomach, leading to a loss of gastric glandular cells and their eventual replacement by intestinal and fibrous tissues. As a result, the stomach's secretion of essential substances such as hydrochloric acid, pepsin, and intrinsic factor is impaired, leading to digestive problems. The most common are vitamin B12 deficiency which results in a megaloblastic anemia and malabsorption of iron, leading to iron deficiency anaemia. It can be caused by persistent infection with Helicobacter pylori, or can be autoimmune in origin. Those with the autoimmune version of atrophic gastritis are statistically more likely to develop gastric carcinoma, Hashimoto's thyroiditis, and achlorhydria.

Atrophy gastritis harbor a high risk for the development of dysplasia and gastric cancer.

Studies

• Associated Factors of Atrophic Gastritis Diagnosed by Double-Contrast Upper Gastrointestinal Barium X-Ray Radiography: A Cross-Sectional Study Analyzing 6,901 Healthy Subjects in Japan
• Serum Prohepcidin Levels Are Lower in Patients with Atrophic Gastritis
• Extensive Atrophic Gastritis Increases Intraduodenal Hydrogen Gas
• Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use
• Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women
• Impact of Helicobacter pylori Immunoglobulin G Levels and Atrophic Gastritis Status on Risk of Metabolic Syndrome
• Noninvasive diagnosis and screening of atrophic gastritis
• A retrospective study assessing the acceleration effect of type I Helicobacter pylori infection on the progress of atrophic gastritis

Prevention/Treatment

• Efficacy of Banxia Xiexin decoction for chronic atrophic gastritis: A systematic review and meta-analysis
• Morroniside protects against chronic atrophic gastritis in rat via inhibiting inflammation and apoptosis.
• Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis.
• Chinese Classical Formula Sijunzi Decoction and Chronic Atrophic Gastritis: Evidence for Treatment Approach?
• Effect of electroacupuncture at Zusanli (ST36) on intestinal microbiota in rats with chronic atrophic gastritis.