Microglia

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Unraveling Niche Specific Function of Microglia in Normal & Outer Retinal Degenerative States, Saban

Microglia are innate immune system cells which reside in the central nervous system (CNS). Resting microglia regulate the homeostasis of the CNS via phagocytic activity to clear pathogens and cell debris. Sometimes, however, to protect neurons and fight invading pathogens, resting microglia transform to an activated-form, producing inflammatory mediators, such as cytokines, chemokines, iNOS/NO and cyclooxygenase-2 (COX-2). Excessive inflammation, however, leads to damaged neurons and neurodegenerative diseases (NDs), such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS).

Articles/Studies

Microglia Are Key Players in Awakening the Brain Post-Anesthesia

Polystyrene nanoplastics penetrate across the blood-brain barrier and induce activation of microglia in the brain of mice.

This review summarizes the beneficial effects of gastrodin acting on activated microglia along with other herbal compounds.

Microglial control of astrocytes in response to microbial metabolites

Inflammatory Microglial Activity In Neurodegenerative Diseases

Inhibitors of microglial neurotoxicity: focus on natural products.

Cannabinoid Signaling Plays Role In Regulation Of Microglial Activity

Novel combination of choline with Withania somnifera and Bacopa monnieri reduced oxidative stress in microglia cells, promoting neuroprotection.

Upregulation of Suppressor of Cytokine Signaling 3 in Microglia by Cinnamic Acid.

Effects of curcumin on microglial cells.

Astaxanthin acts via LRP-1 to inhibit inflammation and reverse lipopolysaccharide-induced M1/M2 polarization of microglial cells

Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects

Attenuation of neuroinflammation in microglia cells by extracts with high content of rosmarinic acid from in vitro cultured Melissa officinalis L. cells.