Selenium Studies
- A Review of Dietary Selenium Intake and Selenium Status in Europe and the Middle East
- Selenium and human health
- Selenium Supplementation in the Prevention of Coronavirus Infections (COVID-19)
- Reduced levels of plasma selenium are associated with increased inflammation and cardiovascular disease.
- Bisphenol A aggravate selenium deficiency-induced apoptosis.
Aging
- A multi-nutrient mixture of vitamin C, vitamin E, carotenoids, selenium, zinc, amino acids and glycosaminoglycans, blueberry extract and pycnogenol improves visible signs of ageing in women 45-73 years of age.
- Dietary supplementation with selenium and coenzyme Q10 combined reduced the inflammatory response in elderly humans.
- Dietary selenium intakes and musculoskeletal function in very old adults.
Anti-inflammatory
Selenium added to chokeberry juice enhances significantly its anti-inflammatory activity.
Antioxidant
Asthma
Selenium may be a useful adjunct to medication for patients with chronic asthma.
Cadmium
Selenium protects against cadmium-induced cardiac injury.
Cancer
- Selenium for preventing cancer.
- Lessons from basic research in selenium and cancer prevention (Review)
- Addition of selenium improves immunomodulative effects of glucan.
- Selenium enhances photodynamic therapy of C-phycocyanin against lung cancer.
- The protective role of selenium on genetic damage and on cancer (Review).
- Phase III randomised chemoprevention study with selenium on the recurrence of non-invasive urothelial carcinoma. The SELEnium and BLAdder cancer Trial
- Colorectal Adenomas in Participants of the SELECT Randomized Trial of Selenium and Vitamin E for Prostate Cancer Prevention.
- Association between selenium and lycopene supplementation and incidence of prostate cancer: Results from the post-hoc analysis of the procomb trial.
- Effect of selenium supplementation for protection of salivary glands from iodine-131 radiation damage in patients with differentiated thyroid cancer.
- Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort.
- Multicenter, phase III trial comparing selenium supplementation with observation in gynecologic radiation oncology: follow-up analysis of the survival data 6 years after cessation of randomization.
- Supplementation with selenium can influence nausea, fatigue, physical, renal, and liver function of children and adolescents with cancer.
- Is the inverse association between selenium and bladder cancer due to confounding by smoking?
- Selenium induces a multi-targeted cell death process in addition to ROS formation.
- Selenium supplementation and prostate cancer mortality.
- The association between selenium and other micronutrients and thyroid cancer incidence in the NIH-AARP Diet and Health Study
- Progression From High-Grade Prostatic Intraepithelial Neoplasia to Cancer: A Randomized Trial of Combination Vitamin-E, Soy, and Selenium.
- Increasing Dietary Selenium Elevates Reducing Capacity and ERK Activation Associated with Accelerated Progression of Select Mesothelioma Tumors
- Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial.
- Selenium as an element in the treatment of ovarian cancer in women receiving chemotherapy
- Selenium and Bladder Cancer Risk: a Meta-analysis
- Multicenter, Phase 3 Trial Comparing Selenium Supplementation With Observation in Gynecologic Radiation Oncology
- Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
- Plasma Selenium, Manganese Superoxide Dismutase, and Intermediate- or High-Risk Prostate Cancer
- Selenium and vitamin E supplementation have a normalizing effect on the serum protein patterns in men with prostate cancer.
- Selenium and lung cancer: A quantitative analysis of heterogeneity in the current epidemiological literature
- Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis
- Selenium in the treatment of head and neck lymphedema
- Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial.
- Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial.
- SELECT: the selenium and vitamin E cancer prevention trial.
- Selenium in the treatment of radiation-associated secondary lymphedema.
- Selenium decreased the cisplatin induced histopathological changes in the brain indicating a protective effect.
- Oral selenium is a good candidate for chemoprevention in women who carry a mutation in the BRCA1 gene.
- Consumption of a high-fat diet abrogated the anti-metastatic effects of selenium.
- Selenium regulates cyclooxygenase-2 and extracellular signal-regulated kinase signaling pathways by activating AMP-activated protein kinase in colon cancer cells.
- Dietary selenium protects against chronic inflammation induced colon cancer in mice.
- Selenium may protect against the development of esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), and gastric cardia adenocarcinoma (GCA).
- Selenium supplementation during radiotherapy is effective in improving blood selenium status in selenium-deficient cervical and uterine cancer patients and reduces the number of episodes and severity of radiation therapy-induced diarrhea.
Cardiovascular Effects
- Selenium attenuates adriamycin-induced cardiac dysfunction via restoring expression of ATP-sensitive potassium channels in rats
- Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly
- Serum selenium concentration and risk of ischaemic heart disease in a prospective cohort study of 3000 males
- Selenium alleviates apoptosis induced by fluoride through improving the expression of HSP70 and reduces oxidative stress.
- Selenium and coenzyme Q10 improve the systemic redox status while reducing cardiovascular mortality in elderly population.
Celiac Disease
Cognitive
New horizons for the role of selenium on cognitive function.
COPD
COVID-19
- Selenium in the prevention of SARS-CoV-2 and other viruses.
- Can selenium reduce the susceptibility and severity of SARS-CoV-2?
Cystic Fibrosis
Dementia
- Selenium induced protective effects against experimental dementia-induced brain, and blood oxidative injuries and apoptosis.
- Association of Antioxidant Supplement Use and Dementia in the Prevention of Alzheimer’s Disease by Vitamin E and Selenium Trial (PREADViSE)
Depression
Selenium seems to have a protective role against postpartum depression.
Diabetes
- Selenium supplementation among diabetic nephropathy patients had favourable effects on serum MMP-2, plasma NO, TAC and GSH.
- The effects of selenium supplementation on biomarkers of inflammation and oxidative stress in patients with diabetic nephropathy: a randomised, double-blind, placebo-controlled trial
- Effects of Long-Term Selenium Supplementation on the Incidence of Type 2 Diabetes: A Randomized Trial.
HIV
Hyperthyroidism
Selenium supplementation can enhance biochemical restoration of hyperthyroidism.
IBS
Selenium deficiency induces irritable bowel syndrome.
Immune System Effects
Selenium, Selenoproteins, and Immunity
The regulation of pathways of inflammation and resolution in immune cells and cancer stem cells by selenium.
Immune System Effects
Selenium deficiency not only weakens the host immune system against viral infections but also leads to viral genome mutations from benign variants to highly pathogenic viruses ^[R]. Inadequate antioxidant protection against various mutating RNA viruses, including SARS-CoV, has been observed in individuals with blood selenium concentrations <1 μM/L ^[R]. Human selenium deficiency decreases the production of free radicals and impairs the functions of neutrophils, T cells, lymphocytes, NK cells, and thymocytes ^[R]. Selenium enhances the polarization of M1 macrophages (proinflammatory) to M2 (anti-inflammatory) macrophages ^[R]. Selenium may exert its anti-inflammatory effect through epigenetic modulation of inflammatory gene expression, such as NF-κB, and subsequently, reduce the synthesis of proinflammatory cytokines ^[R. Several clinical studies revealed the beneficial effects of selenium supplementation on the increasing lymphocyte proliferation, improving NK cell activity, and enhancing IL-2 receptor expression ^[R].
Most of the beneficial effects of selenium in reducing the risk for viral infections are due to its incorporation in the form of selenocysteine into a group of proteins that are named selenoproteins; many of which are potent antioxidant enzymes, like glutathione peroxidases and thioredoxin reductases [R}. Selenium exerts an antiviral effect via its modulatory role in antioxidant defense, redox signaling, and redox homeostasis ^[R]. Selenium alone or in combination with other nutrients exerts an accelerated cellular antiviral immune response and mediates resistance to different viruses, such as influenza A ^[R]. Selenium supplementation enhanced plasma selenium levels and increased the cellular immune response in individuals with low plasma selenium challenged with an oral live attenuated poliomyelitis vaccine, presumably via a greater production of IFN-γ and other cytokines ^[R]. Furthermore, selenium exerts a potent control over virus pathogenicity, and a direct link between selenium deficiency and increased risk for the occurrence and progression of some viral infections has been reported ^[R]. Administration of sodium selenite effectively prevented Keshan disease, congestive cardiomyopathy caused by a combination of selenium deficiency and a mutated strain of Coxsackievirus ^[R].
Kidneys
Liver Effects
Memory Loss
Natural Mineral May Help Reverse Memory Loss Selenium, a natural mineral found in grains, meats, and nuts can reverse cognitive impairment following a stroke and improve learning and memory in the aging brain.
Mercury Toxicity
Metabolic Disorders
Nephroprotective
Nephroprotective efficacy of selenium and zinc against potassium dichromate-induced renal toxicity.
Obesity/Overweight
Preterm Infants
Prostate Effects
- Analytical accuracy and reliability of commonly used nutritional supplements in prostate disease.
- Selenium Form-Dependent Anti-Carcinogenesis: Preferential Elimination of Oxidant-Damaged Prostate Cancer Cell Populations by Methylseleninic Acid is Not Shared by Selenite
- A combination of selenium and silymarin led to a significant reduction in PSA levels.
- A combination of selenium, vitamin E and soy isoflavones reduces PSA levels and lower risk of prostate cancer in men with high-grade intraepithelial neoplasia.
Radiation Protection
Selenium could alleviate radiation-induced toxicity on the most of the evaluated parameters in this study. The spermatogenesis system is one of the most radiosensitive organs in the body. A usual therapeutic dose of radiation such as the conventional 2 Gy in each fraction of radiotherapy and lower doses seen in diagnostic radiology or a radiation disaster affect the process of spermatogenesis potently. Selenium and zinc are two important elements playing key roles in the development of sperms and also have radioprotective effects.
Rheumatoid Arthritis
Sinusitis
Thyroid Effects
Hashimoto's
- Selenium is therapeutic in Hashimoto's thyroiditis.
- L-selenomethionine supplementation causes a significant decrease in anti-thyroid peroxidase levels in patients with Hashimoto's disease.
Other Effects
- Selenium enriched spirulina protects INS-1E cells from hIAPP-induced cell death through preventing ROS overproduction, mitochondrial dysfunction.
- A combination of coenzyme10, vitamin E, selenium, methionine and phospholipids protects against occupational and environmental stress in workers of the gas and oil industry.