Encephalomyelitis

Encephalomyelitis is a general term for inflammation of the brain and spinal cord, describing a number of disorders. The experimental autoimmune encephalomyelitis, sometimes experimental allergic encephalomyelitis (EAE) is an animal model of brain inflammation. It is an inflammatory demyelinating disease of the central nervous system (CNS). It is mostly used with rodents and is widely studied as an animal model of the human CNS demyelinating diseases, including multiple sclerosis and acute disseminated encephalomyelitis (ADEM). EAE is also the prototype for T-cell-mediated autoimmune disease in general.

Beta-Lapachone ameliorization of experimental autoimmune encephalomyelitis.

Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase.

CBD markedly improved the clinical signs of experimental autoimmune encephalomyelitis and reduced infiltration, demyelination and axonal damage.