Estrogen

From: Traumatic Brain Injury, Panhypopituitarism and Hormonal Evaluations as a Standard of Care
<a href="http://www.nevadaosteopathic.org/attachments/article/33/Clearfield%20Panhypopituitarism%20and%20TBI.pdf">http://www.nevadaosteopathic.org/attachments/article/33/Clearfield%20Panhypopituitarism%20and%20TBI.pdf</a>

Estrogen in Men
Estrogen levels increase as men age due to:
• Increases in aromatase activity
• Obesity
• Alcohol excess
• Environmental estrogens
• Estrogen containing food
• Zinc deficiency
• Liver dysfunction
• Supraphysiologic Testosterone Therapy
• Calcium deficiency
• Diabetes
Optimal Levels 20-30 pg/ml

Avoid Estrogen Excess w Physiologic T Doses
• Use Physiologic Dose
– Age 25-35 (M)Mean T Production=4.1-11 mg/d
» (F) Mean T Production=1.42-2.85 mg/d
– Males: 40-80 mg IM weekly or 40 mg q.o.d.
• Pellets: 500-1200 mg/Rx. (Lasts 4-6 mo.)
– Females 10-20 mg/wk.
• Pellets: 80-150 mg/Rx.

Avoid Estrogen Excess w Physiologic T Doses
Neuroprotective
• Maintains cerebral blood flow, lactate production • Lowers risk of PTSD after trauma. • Modulates pain. • Strongest predictor of acute mortality and poor long-term
outcome. • Decreases risk, onset and progression of neurological
deterioration
• Alzheimer’s Disease, schizophrenia
• Aids in recovering from stroke and TBI.

Avoid Estrogen Excess and Use of E Blocker RX
• Zinc Citrate (30-90 mg/d)
• Quercetin (250 -500 mg/d)
• Glycyrrhiza – licorice
• Grape seed extracts composed mainly of proanthocyanidins
• Resveratrol
• DIM (1-3 gm/d p.o.}
• Chrysin (250 mg bid p.o., topical 50 mg/d)
• Progesterone Cream 2-5%, Caps 10-15 mg/d
• Myomin
• Berberine
• Vitamin K
• Anastrozole (0.5-1.0 mg 1-3x/wk)

Testosterone, Estrogen and Depression Post TBI
Protocol includes adding in upstream hormones shut down by T:
– Pregnenolone-stimulate progesterone
production=neuroprotective
– DHEA-improves myelin sheath