Notes 4

Children

"Sleep Circuits"
+1 Anxiety Disorders
+1 Immune, Autoimmune, Neurologic and Inflammation
+1 Neuroinflammation
+1 The relationship between sleep and wakefulness may depend on the balance of activity in the GABA/galaninergic systems and orexin/hypercretin systems of the posterior hypothalamus
+1a GABA/galaninergic systems
+1a Inflamation
+1a Secondary Damage
+1b Regions Affected by Head Injury (Possible)
+2 Cognition Problems and Compensation
+2 Dorsolateral PFC Region Associated with OCD
+2 Frontal Lobe
+3 Neurological Dysfunction
+3b Neuroimmune and neuroendocrine processes
+6 Bidirectional Communication Between Immune and Neuroendocrine Systems
1 Abnormalities in bioenergetic function
1 Body Systems (Common Causes and Cofactors)
1 Body Systems Treatment
1 Brain Regions and Specific Classes/Systems
1 Changes from Head Injury Testing
1 Consistent Abnormalities found in CFS patients
1 Descriptor
1 Metabolism and Energy Production Dysfunction
1 pTBI-CF, TBI
10 Nervous System
11 Sleep
2 Effects and Systems Effects
2 Orthostatic/neurally Mediated Hypotension/Postural orthostatic tachycardia syndrome (POTS)
21 Neurovascular Unit (NVU)
3 Cofactors (Common)
3 Common and Uncommon Causes and Cofactors
3 Drugs used for CFS (and CFS cofactors)
4 Cholinergic
4 Common Comorbid Diseases (Common) and Uncommon Causal Diseases (Uncommon)
4 Drugs used for TBI (also helpful for CFS)
4 Endocrine system (and alterations to system)
4 Metabolic Dysfunction
4 of the Endocrine System, Common Comorbid Diseases (Common) and Uncommon Causal Diseases (Uncommon)
5 Hormone Replacement Therapy (HRT)
8 Chronic Immune Activation
8 Models Systems (Under Construction)
Abnormalities in lymphocyte function in CFS
Abnormalities of Gene Expression in the Blood
ACTH
Acting as "Micro-Hormones" fine tuning “Macro-Hormones” activity in brain
Addiction
Adoptive Immune Therapy to Enhance Microglial-directed Neuronal Repair and Maintenance
ADRA1A receptors
Altered Neural Activity
AMPK
Anosmia (loss of smell)
Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome
Astrocytes
Basal Hypocortisolism
Behavioral, Neurobehavioral and Psychiatric changes from head injury
Blood Brain Barrier and disorders
Brain
Brain Fog, Confusion, Sensory overstimulation, memory difficulties, pseudopsychopathy, High Effort in processing Planning Administrative Executive Function Planning Anxiety Stress Passive vs Proactive Shy Withdrawn Uncertain w social self esteem and anxiety etc Dysthymia etc
Brain Regions Associated with OCD
Central nervous system (Brain and Spinal Cord), Interneurons
Cerebrospinal Fluid (CNS)
Corticosteroids
Corticotropin-releasing hormone (CRH)
Cortisol
Cortisol Levels
Cytokines
Damage to Frontal cortex and synapses
Diagnostic Imaging
Dr. Holtorf’s
Dr. Sarah Myhill
Drugs and Alcohol interact differently
Dysregulation of the Interferon Pathway
Endocrine Glands
Endothelial Dysfunction
Enzymes
Estradiol
Estrogen
Executive Function
Fatigue (customary or chronic)
Fatigue from TBI and Factors contributing to chronic fatigue after traumatic brain injury
Four Major Neuroendocrine Systems (Axes) through Which the Hypothalamus and Pituitary Direct Neuroendocrine Function
Frequent Urination
Gene Regulation (Surpession and Expression)
Glia and Microglia Cells
Heavy Metals and voc
HGH (Growth Hormone) and Growth Hormone Deficiency (GHD)
Homeostasis is Dynamic Equilibrium within and without Internal and Environment
Hormonal testing
Hormones
HPA axis
Hypocortisolemia, Hypocortisolism
Hypopituitarism
Hypothyroidism
Immune Modulators in conjunction with HRT
Impact of Traumatic Brain Injury on Neurotransmitter Systems
Impaired Activation of the Hypothalamic-Pituitary-Adrenal Axis
Infection-triggered disease onset, chronic immune activation and autonomic dysregulation in CFS point to an autoimmune disease directed against neurotransmitter receptors.
Irregularities, Inhibition, Damage or Dysfunction
Kindling Theory
Lowered Baseline Glucocorticoid Levels
Medical Hypothesis
Medicines that aid in Memory post TBI
Medicines to aid Attention and Processing Speed post TBI
Medicines to aid Executive Function post TBI
Microglial Activation
Millennium WAF Project
Mitochondria in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies
Mitochondrial Inhibition, Damage and Hypometabolism
Molecular Functions Associated With Fatigue
Mood and Anxiety Disorders Following Traumatic Brain Injury
Neural Circuits/Networks, Axes and Pathways
Neuroendocrine Changes
Neuroendocrine changes from TBI
Neuroenzyme Pathways
Neurometabolism
Neurons
Neurons, Neurotransmitters and Neurotransmitter Systems, Receptors, Synapses and Synaptic Communication
Neurosteroidal Systems
Neurosteroidogenic Enzymes
Neurotransmitters and Neurotransmitter Systems
Nicotinamide
NK Cells
OCD
One of the most common characteristics of frontal lobe damage is difficulty in interpreting feedback from the environment.
Patient experience
Patient Model
Pharmacological Medicine for Traumatic Brain-injury Rehabilitation by class
Pregnenolone
Progesterone
Prolactin
Reduced Absolute Cortical Blood Flow in CFS
Reduced Cortisol
Regions
rise of autoantibodies against key enzymes in energy metabolism causing defective aerobic energy metabolism and PEM (post exertional malaise)
Ritalin (Methylphenidate)
Secondary Hormones in HRT Treatment
Secretagogues in conjunction with HRT
Signaling
Sleep aid drugs
Sleep Disturbances, CFS as sleep disorder
Spinal Fluid Abnormalities in Patients with Chronic Fatigue Syndrome
Steroid Hormones
Supplements in conjunction with HRT
syndrome of inappropriate antidiuretic hormone (SIADH)
TBI increases mitochondrial fission and that inhibition of fission improves hippocampal-dependent learning and memory
Testing
Testing for amount and kind of brain cells by evaluating R2t* signal from MRI scan
Testosterone
The primary brain regions sensitive to acute exercise and symptoms of Post Exertional Malaise are the inferior frontal, parietal and cingulate cortices (regions critical for efficient cognitive processing involving processes associated with attention, error detection, and cognitive control/central executive functions)
Thyroid
Thyroid hormones
Treatment for TBI
Types of Hormones
Vagus Nerve Infection Hypothesis (VNIH)
Vitamin D
What it feels like and how to explain to family and friends
Zona Fasciculata

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