Mast Cell Triggers

<p>Stimulating degranulation
Acetylcholine
Adenosine
Complement fragments
- C3&alpha;, C4&alpha;, C5&alpha;
Drugs
- Local anesthetics, lactam antibiotics, neuromuscular junction blockers, vancomycin
Eosinophil granule proteins
IgE
IgG1
IgG4
Lysophosphatidylserine
Histamine
Serotonin
Lysophosphatidic acid
Peptides
- Adrenomedullin, CGRP, Endorphin, Endothelin, Hemokinin-1, Leptin, Mastoparan,
Neurotensin, NGF, PTH, Somatostatin, SP, Thrombin, VIP
Tryptase
Stimulating selective release of mediators without degranulation
ATP
Borrelia burgdorferi (Lyme Disease)
CRH
Heavy metals
- Aluminum, cadmium, mercury
Herbicides
- Atrazine, glyphosate
IL-33
Mycotoxins
LPS
SCF
Viruses</p>