The Default Mode Network (Increased activity)

<p>From: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051500/">Brain function characteristics of chronic fatigue syndrome: A task fMRI study</a></p>

<p>The SampEn of tfMRI signals in activated regions reflects the brain's adaptability to cognitive challenges, while rsfMRI signal fluctuation is believed to be driven by spontaneous background activity. One of our recent studies showed that the BOLD SampEn in the posterior cingulate cortex (PCC) is higher in CFS patients in both rsfMRI and tfMRI (<a class=" bibr popnode" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051500/#bb0230">Shan et al., 2018</a>). The PCC is the primary and driving hub for spontaneous activity in the default mode network. Results from this study and our previous study (<a class=" bibr popnode" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051500/#bb0230">Shan et al., 2018</a>) have therefore shown a BOLD signal variation pattern in CFS, lower BOLD SampEns in regions activated by randomized Stroop tasks and higher SampEns of spontaneous default mode network BOLD fluctuation.</p>