Decrease in White matter, Grey Matter (and lesions?)

<a href="http://med.stanford.edu/news/all-news/2014/10/study-finds-brain-abnormalities-in-chronic-fatigue-patients.html">Study finds brain abnormalities in chronic fatigue patients | News Center | Stanford Medicine</a>

There is less white matter in brains of cfs patients (in certain regions) as well as lesions on the outside (of those regions) and white matter abnormalities in the right hemisphere.

Less Grey Matter, From: <a href="https://link.springer.com/article/10.1007/s12035-017-0598-z">A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): is There a Common Cause? | SpringerLink</a>

In the first relatively large study consisting of 28 CFS patients and 28 healthy controls, these authors reported significant reductions in global GM volume in CFS and that the extent of such reductions correlated with the degree of physical disability [<a title="View reference" href="https://link.springer.com/article/10.1007/s12035-017-0598-z#CR190">190</a>]. In the later study, these authors also reported a global reduction in GM volume which increased significantly, albeit slightly (approximately 6%), following a course of CBT [<a title="View reference" href="https://link.springer.com/article/10.1007/s12035-017-0598-z#CR191">191</a>]. Finally, in their longitudinal MRI study, Shan and others have recently reported a progressive decrease in WM volumes in the left inferior fronto–occipital fasciculus in a cohort of 15 CFS participants (unchanged in 10 normal controls), with decreased regional WM volumes in adjacent regions and GM volume reduction in contralateral regions over a 6-year period; these regional WM and GM volumes once again correlated with illness severity

other conditions (may) include maladaptive stress response (see Seretonin downregulator medicine trials of Cortene <a class="thought-link" href="brain://api.thebrain.com/zBeZ4L6q6n0BlcEIzuFxfQ/jOoiG8XZ0UyB91S0Hl0aTA/CorteneCt38ASeretoninDownregulator">Cortene (CT38) (a Seretonin Downregulator)</a>)

From: <a href="https://link.springer.com/article/10.1007/s12035-017-0598-z">A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): is There a Common Cause? | SpringerLink</a>

There is copious evidence of abnormalities in resting-state functional network connectivity states, grey and white matter pathology and impaired cerebral perfusion in patients afforded a diagnosis of multiple sclerosis, major depression or chronic fatigue syndrome (CFS) (myalgic encephalomyelitis)

From: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633338/">Grey and white matter differences in Chronic Fatigue Syndrome – A voxel-based morphometry study</a>

Elevated GM volume in CFS is seen in areas related to processing of interoceptive signals and stress. Reduced WM volume in the patient group partially supports earlier findings of WM abnormalities in regions of the midbrain and brainstem.