Roche
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</div><div>http://en.wikipedia.org/wiki/Hoffmann-La_Roche</div><div>
</div><div><p style="margin: 0.5em 0px; line-height: 22.3999996185303px; color: rgb(37, 37, 37); font-size: 14px; background-color: rgb(255, 255, 255);"><b>F. Hoffmann-La Roche AG</b> is a <a href="http://en.wikipedia.org/wiki/Switzerland" title="Switzerland" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Swiss</a> global health-care company that operates worldwide under two divisions: <a href="http://en.wikipedia.org/wiki/Pharmaceutical_company" title="Pharmaceutical company" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Pharmaceuticals</a> and <a href="http://en.wikipedia.org/wiki/Roche_Diagnostics" title="Roche Diagnostics" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Diagnostics</a>. Its <a href="http://en.wikipedia.org/wiki/Holding_company" title="Holding company" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">holding company</a>,<b>Roche Holding AG</b>, has bearer shares listed on the <a href="http://en.wikipedia.org/wiki/SIX_Swiss_Exchange" title="SIX Swiss Exchange" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">SIX Swiss Exchange</a>.</p><p style="margin: 0.5em 0px; line-height: 22.3999996185303px; color: rgb(37, 37, 37); font-size: 14px; background-color: rgb(255, 255, 255);">The company headquarters are located in <a href="http://en.wikipedia.org/wiki/Basel" title="Basel" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Basel</a> and the company has many pharmaceutical and diagnostic sites around the world – including: <a href="http://en.wikipedia.org/wiki/Pleasanton,California" title="Pleasanton, California" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Pleasanton, CA</a>; <a href="http://en.wikipedia.org/wiki/Vacaville,California" title="Vacaville, California" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Vacaville, California</a>, <a href="http://en.wikipedia.org/wiki/Oceanside,California" title="Oceanside, California" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Oceanside, California</a>, <a href="http://en.wikipedia.org/wiki/Branchburg" title="Branchburg" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Branchburg</a>, NJ; <a href="http://en.wikipedia.org/wiki/Indianapolis,Indiana" title="Indianapolis, Indiana" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Indianapolis, Indiana</a>; <a href="http://en.wikipedia.org/wiki/Florence,South_Carolina" title="Florence, South Carolina" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Florence, South Carolina</a>; and <a href="http://en.wikipedia.org/wiki/Ponce,Puerto_Rico" title="Ponce, Puerto Rico" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Ponce, Puerto Rico</a> in the US; <a href="http://en.wikipedia.org/wiki/Welwyn_Garden_City" title="Welwyn Garden City" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Welwyn Garden City</a> and <a href="http://en.wikipedia.org/wiki/Burgess_Hill" title="Burgess Hill" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Burgess Hill</a> in the UK; <a href="http://en.wikipedia.org/wiki/Clarecastle" title="Clarecastle" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Clarecastle</a> in Ireland; <a href="http://en.wikipedia.org/wiki/Mannheim" title="Mannheim" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Mannheim</a> and <a href="http://en.wikipedia.org/wiki/Penzberg" title="Penzberg" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Penzberg</a> in Germany; <a href="http://en.wikipedia.org/wiki/Mississauga" title="Mississauga" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Mississauga</a> and <a href="http://en.wikipedia.org/wiki/Laval,Quebec" title="Laval, Quebec" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Laval</a> in Canada; <a href="http://en.wikipedia.org/wiki/Shanghai" title="Shanghai" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Shanghai</a> in China; <a href="http://en.wikipedia.org/wiki/Mumbai" title="Mumbai" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Mumbai</a> & <a href="http://en.wikipedia.org/wiki/Hyderabad,India" title="Hyderabad, India" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Hyderabad</a> in India; <a href="http://en.wikipedia.org/wiki/S%C3%A3o_Paulo" title="São Paulo" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">São Paulo</a>, Brazil; <a href="http://en.wikipedia.org/wiki/Segrate" title="Segrate" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Segrate</a>, <a href="http://en.wikipedia.org/wiki/Milan" title="Milan" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Milan</a> in Italy; <a href="http://en.wikipedia.org/wiki/Johannesburg" title="Johannesburg" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Johannesburg</a> in South Africa; <a href="http://en.wikipedia.org/wiki/Karachi" title="Karachi" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Karachi</a>, <a href="http://en.wikipedia.org/wiki/Islamabad" title="Islamabad" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Islamabad</a> and <a href="http://en.wikipedia.org/wiki/Lahore" title="Lahore" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Lahore</a> in Pakistan. There are 26 manufacturing sites worldwide.</p><p style="margin: 0.5em 0px; line-height: 22.3999996185303px; color: rgb(37, 37, 37); font-size: 14px; background-color: rgb(255, 255, 255);">The company owns the American biotechnology company <a href="http://en.wikipedia.org/wiki/Genentech" title="Genentech" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Genentech</a>, which is a wholly owned affiliate, and the Japanese biotechnology company <a href="http://en.wikipedia.org/wiki/Chugai_Pharmaceutical_Co." title="Chugai Pharmaceutical Co." style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Chugai Pharmaceuticals</a> as well as the Tucson, Arizona based <a href="http://en.wikipedia.org/wiki/Ventana_Medical_Systems" title="Ventana Medical Systems" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Ventana</a>. Roche's revenues during fiscal year 2014 were 47.46 billion <a href="http://en.wikipedia.org/wiki/Swiss_franc" title="Swiss franc" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Swiss francs</a>,<sup id="cite_ref-FR14_1-5" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-FR14-1" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[1]</a></sup> or approximately US$48 billion. Roche is the third-largest pharma company worldwide.<sup id="cite_ref-pharmexec50_2-0" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-pharmexec50-2" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[2]</a></sup> Descendants of the founding Hoffmann and Oeri families own slightly over half of the bearer shares with voting rights (a pool of family shareholders 45%, and Maja Oeri a further 5% apart), with Swiss pharma firm <a href="http://en.wikipedia.org/wiki/Novartis" title="Novartis" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Novartis</a> owning a further third of its shares. Roche is one of the few companies increasing their dividend every year, for 2013 as the 27th consecutive year.<sup id="cite_ref-3" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-3" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[3]</a></sup> F. Hoffmann-La Roche is a full member of the <a href="http://en.wikipedia.org/wiki/European_Federation_of_Pharmaceutical_Industries_and_Associations" title="European Federation of Pharmaceutical Industries and Associations" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">European Federation of Pharmaceutical Industries and Associations</a> (EFPIA).<sup id="cite_ref-4" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-4" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[4]</a></sup></p><p style="margin: 0.5em 0px; line-height: 22.3999996185303px; color: rgb(37, 37, 37); font-size: 14px; background-color: rgb(255, 255, 255);" /><div id="toc" class="toc" style="border: 1px solid rgb(170, 170, 170); padding: 7px; font-size: 13.3000001907349px; display: table; zoom: 1; color: rgb(37, 37, 37); background-color: rgb(249, 249, 249);"><div id="toctitle" style="direction: ltr; text-align: center;"><h2 style="color: black; margin: 1em 0px 0.25em; overflow: hidden; padding: 0px; border: none; font-size: 13.3000001907349px; display: inline; line-height: 1.3; background: none;">Contents</h2> <span class="toctoggle" style="-webkit-user-select: none; font-size: 12.5020008087158px;"> [<a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#" id="togglelink" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">hide</a>] </span></div><ul style="line-height: 1.6; list-style-type: none; margin: 0.3em 0px; padding: 0px; list-style-image: none;"><li class="toclevel-1 tocsection-1" style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#History" style="text-decoration: none; color: rgb(11, 0, 128); background: none;"><span class="tocnumber">1</span> <span class="toctext">History</span></a></li><li class="toclevel-1 tocsection-2" style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#Products" style="text-decoration: none; color: rgb(11, 0, 128); background: none;"><span class="tocnumber">2</span> <span class="toctext">Products</span></a></li><li class="toclevel-1 tocsection-3" style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#Controversies" style="text-decoration: none; color: rgb(11, 0, 128); background: none;"><span class="tocnumber">3</span> <span class="toctext">Controversies</span></a></li><li class="toclevel-1 tocsection-4" style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#Collaborative_research" style="text-decoration: none; color: rgb(11, 0, 128); background: none;"><span class="tocnumber">4</span> <span class="toctext">Collaborative research</span></a></li><li class="toclevel-1 tocsection-5" style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#Bibliography" style="text-decoration: none; color: rgb(11, 0, 128); background: none;"><span class="tocnumber">5</span> <span class="toctext">Bibliography</span></a></li><li class="toclevel-1 tocsection-6" style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#See_also" style="text-decoration: none; color: rgb(11, 0, 128); background: none;"><span class="tocnumber">6</span> <span class="toctext">See also</span></a></li><li class="toclevel-1 tocsection-7" style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#References" style="text-decoration: none; color: rgb(11, 0, 128); background: none;"><span class="tocnumber">7</span> <span class="toctext">References</span></a></li><li class="toclevel-1 tocsection-8" style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#External_links" style="text-decoration: none; color: rgb(11, 0, 128); background: none;"><span class="tocnumber">8</span> <span class="toctext">External links</span></a></li></ul></div><p style="margin: 0.5em 0px; line-height: 22.3999996185303px; color: rgb(37, 37, 37); font-size: 14px; background-color: rgb(255, 255, 255);" /><h2 style="font-weight: normal; margin: 1em 0px 0.25em; overflow: hidden; padding: 0px; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-family: 'Linux Libertine', Georgia, Times, serif; line-height: 1.3; background: none rgb(255, 255, 255);"><span class="mw-headline" id="History">History</span><span class="mw-editsection" style="-webkit-user-select: none; font-size: small; margin-left: 1em; vertical-align: baseline; line-height: 1em; display: inline-block; white-space: nowrap; unicode-bidi: -webkit-isolate; font-family: sans-serif;"><span class="mw-editsection-bracket" style="margin-right: 0px; color: rgb(85, 85, 85); margin-left: 0px;">[</span><a href="http://en.wikipedia.org/w/index.php?title=Hoffmann-La_Roche&action=edit§ion=1" title="Edit section: History" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">edit</a><span class="mw-editsection-bracket" style="margin-left: 0px; color: rgb(85, 85, 85); margin-right: 0px;">]</span></span></h2><p style="margin: 0.5em 0px; line-height: 22.3999996185303px; color: rgb(37, 37, 37); font-size: 14px; background-color: rgb(255, 255, 255);">Founded in 1896 by <a href="http://en.wikipedia.org/wiki/Fritz_Hoffmann-La_Roche" title="Fritz Hoffmann-La Roche" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Fritz Hoffmann-La Roche</a>, the company was early on known for producing various <a href="http://en.wikipedia.org/wiki/Vitamin" title="Vitamin" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">vitamin</a> preparations and derivatives. In 1934, it became the first company to mass-produce synthetic <a href="http://en.wikipedia.org/wiki/Vitamin_C" title="Vitamin C" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">vitamin C</a>, under the brand name <a href="http://en.wikipedia.org/wiki/Redoxon" title="Redoxon" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Redoxon</a>. In 1957 it introduced the class of <a href="http://en.wikipedia.org/wiki/Tranquilizer" title="Tranquilizer" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">tranquilizers</a> known as <a href="http://en.wikipedia.org/wiki/Benzodiazepine" title="Benzodiazepine" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">benzodiazepines</a> (with <a href="http://en.wikipedia.org/wiki/Diazepam" title="Diazepam" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Valium</a>and <a href="http://en.wikipedia.org/wiki/Flunitrazepam" title="Flunitrazepam" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Rohypnol</a> being the best known members). Roche has also produced various <a href="http://en.wikipedia.org/wiki/HIV_test" title="HIV test" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">HIV tests</a> and <a href="http://en.wikipedia.org/wiki/Antiretroviral_drug" title="Antiretroviral drug" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">antiretroviral drugs</a>. It bought the <a href="http://en.wikipedia.org/wiki/Patent" title="Patent" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">patents</a> for the <a href="http://en.wikipedia.org/wiki/Polymerase_chain_reaction" title="Polymerase chain reaction" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">polymerase chain reaction</a> technique in 1992. It manufactures and sells several <a href="http://en.wikipedia.org/wiki/Cancer" title="Cancer" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">cancer</a> drugs and is a leader in this field. In 1956, the first antidepressant, <a href="http://en.wikipedia.org/wiki/Iproniazid" title="Iproniazid" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">iproniazid</a>, was accidentally created during an experiment while synthesizing <a href="http://en.wikipedia.org/wiki/Isoniazid" title="Isoniazid" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">isoniazid</a>. Originally, it had been intended to create a more efficient drug at combatting <a href="http://en.wikipedia.org/wiki/Tuberculosis" title="Tuberculosis" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Tuberculosis</a>. <a href="http://en.wikipedia.org/wiki/Iproniazid" title="Iproniazid" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Iproniazid</a>, however, revealed to have its own benefits; some people felt it made them feel happier. It was withdrawn from the market in the early 1960s due to toxic side-effects.</p><p style="margin: 0.5em 0px; line-height: 22.3999996185303px; color: rgb(37, 37, 37); font-size: 14px; background-color: rgb(255, 255, 255);">In 1976, an accident at a chemical factory in <a href="http://en.wikipedia.org/wiki/Seveso" title="Seveso" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Seveso</a>, Italy, owned by a subsidiary of Roche caused a large <a href="http://en.wikipedia.org/wiki/Polychlorinated_dibenzodioxins" title="Polychlorinated dibenzodioxins" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">dioxin</a> contamination; see <a href="http://en.wikipedia.org/wiki/Seveso_disaster" title="Seveso disaster" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Seveso disaster</a>. In 1982, the United States arm of the company acquired Biomedical Reference Laboratories for US$163.5 million. That company dated from the late 1960s, and was located in <a href="http://en.wikipedia.org/wiki/Burlington,North_Carolina" title="Burlington, North Carolina" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Burlington, North Carolina</a>. That year Hoffmann–La Roche then merged it with all of its laboratories, and incorporated the merged company as Roche Biomedical Laboratories, Inc. in Burlington. By the early 1990s, Roche Biomedical became one of the largest clinical laboratory networks in the United States, with 20 major laboratories and US$600 million in sales.<sup id="cite_ref-fundingroche_5-0" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-fundingroche-5" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[5]</a></sup></p><p style="margin: 0.5em 0px; line-height: 22.3999996185303px; color: rgb(37, 37, 37); font-size: 14px; background-color: rgb(255, 255, 255);">In 1995 the era of highly active anti-retroviral therapy (HAART) was initiated by the United States FDA's approval of Hoffman LaRoche's HIV protease inhibitor saquinavir. Within 2 years of its approval (and that of ritonavir 4 months later) annual deaths from AIDS in the United States fell from over 50,000 to approximately 18,000 <sup id="cite_ref-6" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-6" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[6]</a></sup> On April 28, 1995 Hoffmann–La Roche sold Roche Biomedical Laboratories, Inc. to National Health Laboratories Holdings Inc. (which then changed its name to <a href="http://en.wikipedia.org/wiki/Laboratory_Corporation_of_America_Holdings" title="Laboratory Corporation of America Holdings" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Laboratory Corporation of America Holdings</a>).<sup id="cite_ref-sec950515_7-0" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-sec950515-7" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[7]</a></sup> Roche acquired <a href="http://en.wikipedia.org/wiki/Syntex" title="Syntex" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Syntex</a> in 1994 and <a href="http://en.wikipedia.org/wiki/Chugai_Pharmaceuticals" title="Chugai Pharmaceuticals" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Chugai Pharmaceuticals</a> in 2002.</p><p style="margin: 0.5em 0px; line-height: 22.3999996185303px; color: rgb(37, 37, 37); font-size: 14px; background-color: rgb(255, 255, 255);">On January 22, 2008, Roche acquired <a href="http://en.wikipedia.org/wiki/Ventana_Medical_Systems" title="Ventana Medical Systems" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Ventana Medical Systems</a> for $3.4 billion.<sup id="cite_ref-8" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-8" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[8]</a></sup> On January 2, 2009, Roche acquired Memory Pharmaceuticals Corp.<sup id="cite_ref-9" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-9" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[9]</a></sup> On March 26, Roche acquired <a href="http://en.wikipedia.org/wiki/Genentech" title="Genentech" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Genentech</a> for $46.8 billion.<sup id="cite_ref-10" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-10" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[10]</a></sup> On 12 March 2009 Roche agreed to fully acquire <a href="http://en.wikipedia.org/wiki/Genentech" title="Genentech" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Genentech</a>, in which it had held a majority stake since 1990,<sup id="cite_ref-11" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-11" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[11]</a></sup> after 8 months of negotiations. As a result of the Genentech acquisition, Roche closed its Palo Alto based research facilities and moved them to their campus that straddles the border between <a href="http://en.wikipedia.org/wiki/Clifton,New_Jersey" title="Clifton, New Jersey" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Clifton, New Jersey</a> and <a href="http://en.wikipedia.org/wiki/Nutley,New_Jersey" title="Nutley, New Jersey" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Nutley, New Jersey</a> while Roche's United States headquarters, located on the site since 1929, was moved to Genentech's facility in South <a href="http://en.wikipedia.org/wiki/San_Francisco" title="San Francisco" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">San Francisco</a>.<sup id="cite_ref-12" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-12" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[12]</a></sup> Genentech became a wholly owned <a href="http://en.wikipedia.org/wiki/Subsidiary" title="Subsidiary" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">subsidiary</a> group of Roche on 25 March 2009.<sup id="cite_ref-13" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-13" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[13]</a></sup></p><p style="margin: 0.5em 0px; line-height: 22.3999996185303px; color: rgb(37, 37, 37); font-size: 14px; background-color: rgb(255, 255, 255);">On April 13, Roche acquired Medingo Ltd., for $160 million.<sup id="cite_ref-14" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-14" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[14]</a></sup> On August 23, 2010, Roche acquired BioImagene, Inc., for $100 million.<sup id="cite_ref-15" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-15" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[15]</a></sup> In 2011, the company received the <a href="http://en.wikipedia.org/wiki/International_Society_for_Pharmaceutical_Engineering" title="International Society for Pharmaceutical Engineering" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">ISPE</a> Facility of the Year Award for Process Innovation for Roche’s “MyDose” Clinical Supply project.<sup id="cite_ref-16" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-16" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[16]</a></sup> On March 15, Roche acquired PVT Probenverteiltechnik GmbH for up to 85 million EUR.<sup id="cite_ref-17" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-17" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[17]</a></sup> On July 19, Roche acquired mtm laboratories AG for up to 190 million EUR.<sup id="cite_ref-18" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-18" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[18]</a></sup> On October 17, Roche acquired Anadys Pharmaceuticals, Inc. for $230 million.<sup id="cite_ref-19" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-19" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[19]</a></sup></p><p style="margin: 0.5em 0px; line-height: 22.3999996185303px; color: rgb(37, 37, 37); font-size: 14px; background-color: rgb(255, 255, 255);">On June 26, 2012, Roche announced the closure of the Nutley/Clifton campus, which was completed in 2013. The property is in the process of remediation.<sup id="cite_ref-20" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-20" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[20]</a></sup> On July 2, 2013, Roche Diagnostics acquired blood diagnostics company Constitution Medical Inc. for $220 million.<sup id="cite_ref-21" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-21" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[21]</a></sup></p><p style="margin: 0.5em 0px; line-height: 22.3999996185303px; color: rgb(37, 37, 37); font-size: 14px; background-color: rgb(255, 255, 255);">On April 7, 2014, Roche announced its intention to acquire IQuum for up to $450 million,<sup id="cite_ref-22" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-22" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[22]</a></sup> as well as the rights to an experimental drug (<a href="http://en.wikipedia.org/w/index.php?title=ORY-1001&action=edit&redlink=1" class="new" title="ORY-1001 (page does not exist)" style="text-decoration: none; color: rgb(165, 88, 88); background: none;">ORY-1001</a>) from Spanish company Oryzon Genomics for $21 million and up to $500 million in milestone payments.<sup id="cite_ref-23" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-23" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[23]</a></sup> On June 2, Roche announced its intention to acquire <a href="http://en.wikipedia.org/w/index.php?title=Genia_Technologies_Inc.&action=edit&redlink=1" class="new" title="Genia Technologies Inc. (page does not exist)" style="text-decoration: none; color: rgb(165, 88, 88); background: none;">Genia Technologies Inc.</a> for up to $350 million.<sup id="cite_ref-24" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-24" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[24]</a></sup> In August 2014, the company agreed to purchase Californian-based pharmaceutical firm <a href="http://en.wikipedia.org/w/index.php?title=InterMune&action=edit&redlink=1" class="new" title="InterMune (page does not exist)" style="text-decoration: none; color: rgb(165, 88, 88); background: none;">InterMune</a> for $8.3 billion, at $74 a share this represents a 38% premium over the final share closing price.<sup id="cite_ref-25" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-25" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[25]</a></sup><sup id="cite_ref-RocheInterMune_26-0" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-RocheInterMune-26" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[26]</a></sup><sup id="cite_ref-Roche_To_Buy_Biotech_Firm_InterMune_For.248.3B_27-0" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-Roche_To_Buy_Biotech_Firm_InterMune_For_.248.3B-27" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[27]</a></sup> In December 2014, the company acquired <a href="http://en.wikipedia.org/wiki/Next-generation_sequencing" title="Next-generation sequencing" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">next-generation sequencing</a>processing company <a href="http://en.wikipedia.org/w/index.php?title=Bina_Technologies&action=edit&redlink=1" class="new" title="Bina Technologies (page does not exist)" style="text-decoration: none; color: rgb(165, 88, 88); background: none;">Bina Technologies</a> for an undisclosed sum.<sup id="cite_ref-28" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-28" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[28]</a></sup> On January 16, 2015, the company annonuced that they would acquire <a href="http://en.wikipedia.org/wiki/Trophos" title="Trophos" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">Trophos</a> for €470 million ($543 million) in order to increase the companies neuromuscular disease presence. The deal will centre around the Phase II and III <a href="http://en.wikipedia.org/wiki/Spinal_muscular_atrophy" title="Spinal muscular atrophy" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">spinal muscular atrophy</a> drug <a href="http://en.wikipedia.org/wiki/Olesoxime" title="Olesoxime" style="text-decoration: none; color: rgb(11, 0, 128); background: none;">olesoxime</a> (TRO19622).<sup id="cite_ref-29" class="reference" style="line-height: 1; unicode-bidi: -webkit-isolate; font-size: 11.1999998092651px;"><a href="http://en.wikipedia.org/wiki/Hoffmann-La_Roche#cite_note-29" style="text-decoration: none; color: rgb(11, 0, 128); white-space: nowrap; background: none;">[29]</a></sup></p></div><div>
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