Furin Protease

Furin: Furin - Wikipedia PCSK3

Furin, also called proprotein convertase subtilisin/kexin 3 (PCSK3), is a calcium- dependent serine endoprotease that processes a wide variety of proproteins involved in cell function and homeostasis. Dysregulation of furin has been implicated in numerous disease states, including cancer and fibrosis.

Furin has also been widely studied owing to its association with many disease states, including cancer, meta- bolic diseases and fibrotic disorders, as well as bacterial and viral infections (Becker et al., 2012; Couture et al., 2015).

Are there crystal structures of the related protein convertases?

XXX