Cannabinoids
VIDEOS
Practical applications of cannabinoids and terpenes
Educational Documentary on Cannabinoid Compounds
Physiological Basis of the Endocannabinoid System, and Phytocannabinoids
Whole Plant Phytocannabinoid Therapy
Clinical application of cannabinoids and terpenes
A cannabinoid is defined as anything that interacts with a cannabinoid receptor (part of the endocannabinoid system)
The resinous cannabinoids (e.g., tetrahydrocannabinol and cannabidiol) are the subject of much current research, despite the persistence of an outdated legal climate surrounding their sole natural source, Cannabis(this has not always been the case; not so long ago, the herb was a standard presence in the U.S. Pharmacopoeia and the Eclectic Materia Medica). Various types of human cells have cannabinoid receptors which interact with our endogenous cannabinoid compound, anandamide, as well as with the omega-3 fatty acids and the isobutylamides from Echinacea. This system is involved in the regulation of inflammatory processes, neuropathic pain perception, muscle relaxation, and the hunger/satiety axis. It is well-established that the cannabinoids are anti-emetic, making Cannabis a useful adjunct treatment for chemotherapy; it can also be helpful for cancer-associated pain and cachexia. Although this herb can be very useful in some patients, people with bipolar disorder or schizophrenia may not tolerate it well. However, when used as a botanical medicine, it has an excellent safety profile compare to that of many pharmaceuticals. (Ganora)
Articles/Studies
- Cannabinoids 101
- Cannabinoids can activate TRPA1, TRPV1 and TRPV2.
- This review organizes the current knowledge in the context of cannabinoids pharmacogenetics.
- Human skin permeation of Delta8-tetrahydrocannabinol, cannabidiol and cannabinol.
- Worms on cannabinoids get the ‘munchies’
Deficiency
- Cannabinoid Deficiency and Its Impact on Human Health and Disease, Part 1 and Part 2
- Cannabinoid Deficiency and Its Impact on Human Health and Disease, Part 3
Benefits
Analgesic
Anti-Inflammatory / Antifibrotic
Antioxidant
Cannabinoids act as antioxidants to modulate cell survival and growth of B lymphocytes and fibroblasts.
Arthritis
- Cannabinoids may have a role to play in arthritis prevention and treatment.
- Cannabinoids might be a suitable treatment for rheumatoid arthritis.
Cancer
- A review of the anti-tumoural actions of cannabinoids.
- Preclinical and clinical assessment of cannabinoids as anti-cancer agents.
- Cannabinoids may be promising tools in combination therapy for breast and prostate cancers.
Cognitive
COVID-19
- Potential neuroprotective effect of cannabinoids in covid-19 patients.
- Anti-inflammatory and antiviral effects of cannabinoids in inhibiting and preventing SARS-CoV-2 infection.
- Cannabinoids as emergent therapy against COVID-19.
Epilepsy
- Cannabinoids in epilepsy: clinical efficacy and pharmacological considerations.
- Cannabinoids could confer neuroprotection against epilepsy.
Gastrointestinal Effects
- A review of cannabinoid pharmacology and therapy in gut disorders.
- Modulatory effect of gut microbiota on the gut-brain, gut-bone axes, and the impact of cannabinoids.
Immune System
- Cannabinoids have the potential to regulate the activation and balance of human Th1/Th2 cells by a CB2 receptor-dependent pathway.
- Cannabinoids alleviate the lipopolysaccharide-induced cytokine storm.
Neuroprotective
- Cannabinoids May Help Limit Secondary Damage of Traumatic Brain Injuries
- Cannabinoid Signaling Plays Role In Regulation Of Microglial Activity
- Cannabinoids have neuroprotective properties.
- A review of the therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis.
- Cannabinoids modulate neuronal activity and cancer by CB1 and CB2 receptor-independent mechanisms.
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