Bisdemethoxycurcumin
Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α,25-dihydroxyvitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC). More stable than curcumin in physiological media, BDMC suppresses proliferation in cancer cells. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression.
Anti-Inflammatory
- MAPKs and NF‑κB pathway inhibitory effect of bisdemethoxycurcumin on phorbol‑12‑myristate‑13‑acetate and A23187‑induced inflammation in human mast ...
- Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism
Arthritis
Atopic Dermatitis
Inhibitory effect of bisdemethoxycurcumin on DNCB-induced atopic dermatitis.
Cancer
- Bisdemethoxycurcumin induces cell apoptosis and inhibits human brain glioblastoma.
- Bisdemethoxycurcumin may have potential as a novel anti-metastasis agent for the treatment of human cervical cancer.
- Bisdemethoxycurcumin suppresses human osteosarcoma U‑2 OS cell migration and invasion.
- Bisdemethoxycurcumin partially offsets the chemoresistance induced by gemcitabine and produces apoptosis in PANC-1 cells.
Gastroprotective
- Dietary bisdemethoxycurcumin supplementation attenuates lipopolysaccharide-induced damages on intestinal redox potential.
- Bisdemethoxycurcumin alleviates dextran sodium sulfate-induced colitis.
- Investigating the mechanisms of bisdemethoxycurcumin in ulcerative colitis.
Lung Injury
Bisdemethoxycurcumin alleviates LPS-induced acute lung injury.