Ulcerative Colitis

See also: Inflammatory Bowel Disease ; Mucoid Diarrhea ; Pyodermatitis ; Diet to Prevent & Treat Ulcerative Colitis ; Stimulate Digestion,Warm the Middle, Resolve Mucous Damp

In 1973, George Engel stated that individuals with ulcerative colitis often became ill after an emotional relationship with a maternal figure was threatened either in fact or in fantasy [R]. Now it is understood that specific bacteria of the Enterobacteriaceae family may act together with a disordered microbiome to increase the risk of ulcerative colitis. Lepage et al. found that patients with ulcerative colitis had significantly less bacterial diversity, including a higher ratio of Actinobacteria and Proteobacteria when compared to their healthy twins. Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis.

Studies over 40 years have associated ulcerative colitis with cytomegalovirus (CMV). A clear association between onset of ulcerative colitis and primary CMV infection was confirmed by viral studies in two patients. Higher frequency and amount of antibodies to CMV were found in patients with ulcerative colitis. The simultaneous presence of DNA from several herpes viruses, including CMV, was much greater in ulcerative colitis patients compared to those with Crohn’s disease or normal controls. While it is debated that CMV infection may be a causative factor in ulcerative colitis, it is recognized by many clinicians as a complicating event that can increase its severity...

Adherent-invasive Escherichia coli (AIEC) are found in significant amounts in patients with ulcerative colitis compared with controls. Several workers have shown that isolates of E.coli obtained from patients with ulcerative colitis can degrade mucins and produce toxins. Results from one study suggested that connective tissue exposed by bowel ulcerations may result in selection of E. coli strains able to bind to them. Compared with healthy people, ulcerative colitis patients have increased levels of IgG directed against their normal flora. There may be an increased number of bowel bacteria in ulcerative colitis, but reduced counts of ‘protective’ bacteria such as Lactobacilli and Bifidobacteria. Lactobacilli numbers were certainly found to be lower in ulcerative colitis patients during the active phase. This was confirmed in another study that also found the bacterial diversity decreased during a relapse.

In patients with active ulcerative colitis there is an over-production of hydrogen sulphide, which is toxic to the intestinal mucosa by competing with short-chain fatty acids. This appears to be due to an excess (or greater activity) of sulphate-reducing bacteria (SRB), such as Desulfovibrio desulfuricans. In a pilot study, a low sulphur diet for 12 months was associated with a remarkable clinical improvement in four patients with chronic ulcerative colitis. A recent review concluded that there is evidence to implicate SRB in the pathogenesis of ulcerative colitis...

As noted in a Lancet review: “The long-standing assumption that ulcerative colitis is an autoimmune disease has been revised to incorporate evidence suggesting that commensal microflora and their products are autoantigens, and that ulcerative colitis is caused by loss of tolerance towards otherwise harmless components of the normal intestinal flora.”

Source:  Principles and Practice of Phytotherapy, 2nd Edition, 2013 by Kerry Bone and Simon Mills. Indicated by (Bone & Mills)

Below is a chart showing the dominant species of gut flora found in ulcerative colitis patients. The green is E.coli, see Gut Florafor comparison with a healthy gut flora and the color code.

VIDEOS

Common Useful Advice & Diet for Ulcerative Colitis Patients By Dr. Vikram Chauhan

Ulcerative colitis: Fresh approaches to taming inflammation

Ayurvedic Medicine for Ulcerative Colitis

Ayurvedic Treatment of Ulcerative Colitis - Classification, Symptoms, Causes & Herbal Remedies

Ayurvedic Treatment of Ulcerative Colitis - Classification, Symptoms, Causes & Herbal Remedies

Permanent Cure through Ayurveda

Common Useful Advice & Diet for Ulcerative Colitis Patients By Dr. Vikram Chauhan

A testimonial on Ulcerative Colitis-with Dr. Marianne Teitelbaum

Ulcerative colitis: Fresh approaches to taming inflammation

Ayurvedic Treatment Testimonial

Ayurvedic Treatment Testimonial

Ayurvedic Treatment Testimonial

Treating Ulcerative Colitis with Diet

How to Stop the Cause

Striking with the Root: Turmeric Curcumin and Ulcerative Colitis

Articles/Studies

Risk Factors

• Dietary Factors in Sulfur Metabolism and Pathogenesis of Ulcerative Colitis
• Ulcerative colitis after statin treatment has been reported.
• Cancer risk linked to p53 in ulcerative colitis
• Measles virus DNA from the MMR vaccine has been found in peripheral mononuclear cells in patients with ulcerative colitis and children with autism, indicating its possible role in the pathogenesis of these disorders.
• Small intestinal bacterial overgrowth** and evaluation of intestinal barrier function in patients with ulcerative colitis.

Prevention

• Oligosaccharide-dependent anti-inflammatory role of galectin-1 for macrophages in ulcerative colitis.
• Hydroxysafflor yellow A protects against ulcerative colitis.
• Licorice protects against ulcerative colitis via the Nrf2/PINK1-mediated mitochondrial autophagy.

Treatment

• How to Treat Ulcerative Colitis with **Diet**(https://nutritionfacts.org/2018/01/16/how-to-treat-ulcerative-colitis-with-diet/)
• Ulcerative Colitis Patients Find New Hope in Herbal Medicine, Meta-Analysis Suggests
• Herbal medicines for the treatment of active ulcerative colitis.
• The significant role of nutraceutical compounds in ulcerative colitis treatment.
• Introducing Traditional Herbal Medicine into Conventional Health Care in Treating Ulcerative Colitis: Primum Non Nocere
• Vitamin D3** alleviates inflammation in ulcerative colitis.
• Co-administration of **thymoquinone and propolis** in liposomal formulations as a potential approach for treatment of acetic acid-induced ulcerative colitis.
• Progress on the mechanisms of **Lactobacillus plantarum** to improve intestinal barrier function in ulcerative colitis.
• Coptis chinensis and berberine** ameliorate chronic ulcerative colitis.
• The healing effect of **Aloe vera gel** on acetic acid-induced ulcerative colitis.
• **Aloe vera gel** could be used to improve the symptoms of ulcerative colitis.
• Randomized, double blind,  placebo-controlled trial of **oral aloe vera gel** for active ulcerative colitis
• Isothiocyanate-enriched moringa seed extract** alleviates ulcerative colitis symptoms in mice
• **Aloe vera and ubiqinol** have a protective and healing effect on experimental ulcerative colitis in rats.
• Apigenin** remodels the gut microbiota to ameliorate ulcerative colitis.
• **Lonicerin** targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation.
• The Therapeutic Effect of **Chelidonic Acid** on Ulcerative Colitis
• The Improving Effect of **Chelidonic Acid** on Ulcerative Colitis
• Systems pharmacology reveals the unique mechanism features of **Shenzhu Capsule** for treatment of ulcerative colitis in comparison with synthetic drugs.
• Ulcerative colitis results in differential metabolism of **cranberry** polyphenols by the colon microbiome in vitro.
• **Fingolimod** in combination with **berberine** at reduced doses represents a novel therapy for ulcerative colitis.
• iTRAQ-based pharmacoproteomics reveals potential targets of **berberine**, a promising therapy for ulcerative colitis.
• Treatment of ulcerative colitis using **fecal bacteriotherapy**.
• **Fecal microbiota transplant** is safe and effective for patients with ulcerative colitis
• Fecal microbiota transplantation** combined with prebiotics ameliorates ulcerative colitis.
• Dietary supplementation with **fish oil** in ulcerative colitis
• **Fish oil** fatty acid supplementation improves mild to moderate ulcerative colitis and reduces or eliminates the need for anti-inflammatory drugs in most patients.
• An oral supplement enriched with** fish oil, FOS, soluble fiber, gum arabic and antioxidants** reduce the need for corticosteroids in ulcerative colitis
• **Cinnamaldehyde and hesperetin** attenuate TNBS-induced ulcerative colitis.
• A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of **Cannabidiol-rich Botanical Extract** in the Symptomatic Treatment of Ulcerative Colitis.
• **Ascorbic acid** contributes to the reduction of oxidative stress and inflammatory response in DSS-induced colitis.
• Limonin** ameliorates ulcerative colitis by regulating STAT3/miR-214 signaling pathway.
• These results suggest that **high-dose vitamin C** administration can improve ulcerative colitis.
• **Paeoniflorin** has the anti-inflammatory effect in ulcerative colitis.
• **Berberine** in the treatment of ulcerative colitis: A possible pathway through Tuft cells.
• **Dandelion** polysaccharide can decrease the level of IL-6 in rats with ulcerative colitis..
• **Dandelion root** extracts abolish MAPK pathways to ameliorate experimental mouse ulcerative colitis.
• **Probiotics** may be effective for maintaining clinical remission in patients with quiescent ulcerative colitis.
• Progress on the mechanisms of **Lactobacillus plantarum** to improve intestinal barrier function in ulcerative colitis.
• **Zeaxanthin** may be an effective therapeutic candidate for the treatment of ulcerative colitis.
• **D-limonene** exhibits anti-inflammatory and antioxidant properties in an ulcerative colitis.
• **Curcumin** appears safe and effective in maintaining remission in patients with quiescent ulcerative colitis.
• Efficacy of **Curcumin** as Adjuvant Therapy to Induce or Maintain Remission in Ulcerative Colitis Patients: an Evidence-based Clinical Review.
• **Curcumin** add-on therapy for ulcerative colitis
• Use of **curcumin** in achieving clinical and endoscopic remission in ulcerative colitis.
• **Curcuminoids** from Curcuma Longa: New adjuvants for the treatment of crohn's disease and ulcerative colitis?
• Curcuminoids** for Ulcerative Colitis: A Review of the Evidence
• **Curcumin** may be a safe and effective therapy for maintenance of remission in quiescent UC when given as adjunctive therapy along with mesalamine or sulfasalazine.
• **Curcumin** maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial
• Efficacy and safety of adjuvant **curcumin** therapy in ulcerative colitis
• These new data support a potential role of **oleuropein** in the treatment of ulcerative colitis.
• **Curcumin** ameliorates experimentally induced ulcerative colitis.
• Old but fancy: **Curcumin** in ulcerative colitis-current overview.
• The effect of **curcumin** supplementation on clinical outcomes and inflammatory markers in patients with ulcerative colitis.
• The efficacy of **curcuminoids** in improvement of ulcerative colitis symptoms and patients' self-reported well-being.
• Oral delivery of **oleuropein-loaded lipid nanocarriers** alleviates inflammation and oxidative stress in acute colitis.
• Isothiocyanate-enriched moringa seed extract** alleviates ulcerative colitis symptoms in mice
• Punica granatum (**pomegranate**) ameliorates dextran sulfate sodium induced ulcerative colitis.
• Dehydroepiandrosterone (**DHEA**) was demonstrated to be safe and effective in patients with refractory Crohn's disease or ulcerative colitis.
• **Resveratrol** protects against chemically-induced ulcerative colitis.
• **Resveratrol** shows beneficial affects on ulcerative colitis
• **L-arginine** augments the antioxidant effect of garlic against acetic acid-induced ulcerative colitis in rats.
• **Melatonin** intervention reduced autophagy by ameliorating inflammation and oxidative stress in a mouse model of colitis-associated colon carcinogenesis.
• **American ginseng** prevents and treats Ulcerative Colitis.
• **Germinated barley** prolongs remission in patients with ulcerative colitis.
• **Germinated barley** significantly reduces clinical symptoms of ulcerative colitis.
• Glycoaminoglycans like **glucosamine** may contribute to improving conditions like ulcerative colitis, Crohn's disease and interstitial cystitis.
• **Wheat grass juice** appears safe and effective in the treatment of distal ulcerative colitis.
• "Dietary unsaponificable fraction from **extra virgin olive oil** supplementation attenuates acute ulcerative colitis in mice."
• A **Frankincense extract** attenuates the symptoms associated with mild Ulcerative Colitis in remission.
• A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of **Cannabidiol-rich Botanical Extract** in the Symptomatic Treatment of Ulcerative Colitis
• Hydroxytyrosol** alleviate intestinal inflammation, oxidative stress and apoptosis resulted in ulcerative colitis.
• Experimental study on effects of **berberine combined with 6-shogaol** on intestinal inflammation and flora in mice with ulcerative colitis.
• Moringa oleifera** can be a potential source of drugs alleviating anxiety and oxidative stress associated to ulcerative colitis.
• Effect of the standard herbal preparation, **STW5**, treatment on dysbiosis induced by dextran sodium sulfate in experimental colitis.
• Sulforaphane** could cure ulcerative colitis in rats.
• Investigating the mechanisms of **bisdemethoxycurcumin** in ulcerative colitis.
• Garcinia mangostana and α-mangostin** revive ulcerative colitis-modified hepatic cytochrome P450 profiles.
• Polysaccharide from fermented mycelium of **Inonotus obliquus (Chaga)** attenuates the ulcerative colitis and adjusts the gut microbiota in mice.
• Tiliroside** Ameliorates Ulcerative Colitis by Restoring the M1/M2 Macrophage Balance via the HIF-1α/glycolysis Pathway.
• 3, 3'-diindolylmethane** alleviates ulcerative colitis.
• Safety and potential role of **Lactobacillus rhamnosus GG** administration as monotherapy in ulcerative colitis patients.
• Inhibitory effect of **Portulaca oleracea** L. aqueous extract and juice on NLRP3 inflammasome activation in an ulcerative colitis model.
• One-year clinical efficacy and safety of **indigo naturalis** for active ulcerative colitis.
• Coconut water** was more effective than placebo for induction of clinical remission in patients with mild to moderate ulcerative colitis.
• Revolutionizing Ulcerative Colitis Care: **Coconut Water's** Potential Unveiled in Landmark Study
• Curcumin-QingDai combination** for patients with active ulcerative colitis.
• 'Green Slime' for Ulcerative Colitis Patients? New Study Shows This Blue-Green Alga Holds Promise Spirulina
• The prophylaxis functions of Lactobacillus fermentum GLF-217 and Lactobacillus plantarum FLP-215 on ulcerative colitis.