NP - structures

(Zinzula Baumeister BBRC 2020 PMID: 33039147)

Small-angle X-ray scattering (SAXS) data have provided low resolution models for the SARS-CoV and recently also for SARS- CoV-2 full length N, showing that NTDs are flexibly tethered to CTD dimers in solution and do not stably interact with each other or with the CTDs, and that the protein is largely disordered at physi- ological temperature due to the dynamic extension of its IDRs [39,44].

Overall NP structure

pmid: 32416961 /2020 : CD spectra showed that it has a high percentage of disordered region at room temperature while it was best structured at 55 °C, suggesting its structural dynamics.